Since protein complex crystallization is expensive and time-consuming, computational docking tools provide a valuable method to investigate protein interactions. While the sampling of possible docked conformers of two proteins can be performed efficiently by Fast Fourier Transform (FFT) methods, the selection of near-native decoys from the pool of thousands of possible decoys is still far from ...

In typical Data Grids large amounts of replicated data are stored all over the globe in different storage systems with access latencies ranging from seconds to hours. The task of a replica management system is not only to keep track of the replicas but also to select those replicas that can be accessed by an application program with a minimal response or transfer time. Most wide-area replicatio...

Data Grid supports data-intensive applications in a large scale grid environment. It makes use of storage systems as distributed data stores by replicating contents. On the co-allocation architecture, the client can divide a file into k blocks of equal size and download the blocks dynamically from multiple servers by GridFTP in parallel. But the drawback is that faster servers must wait for the...

Joint user selection (US) and vector precoding (US-VP) is proposed for multiuser multiple-input multiple-output (MU-MIMO) downlink. The main difference between joint US-VP and conventional US is that US depends on data symbols for joint US-VP, whereas conventional US is independent of data symbols. The replica method is used to analyze the performance of joint US-VP in the large-system limit, w...

When executing time-sensitive distributed applications, a middleware that provides dependability and timeliness is faced with the important problem of preventing timing failures both under normal conditions and when the quality of service is degraded due to replica failures and transient overload on the server. To address this problem, we have designed a probabilistic model-based replica select...

Content Delivery Networks (CDN) aim at overcoming the inherent limitations of the Internet. The main concept at the basis of this technology is the delivery at edge points of the network, in proximity to the request areas, to improve the user’s perceived performance while limiting the costs. This paper focuses on the main research areas in the field of CDN, pointing out the motivations, and ana...

The quantum random energy model provides a mean-field description of the equilibrium spin glass transition. We show that it further exhibits a many-body localization-delocalization (MBLD) transition when viewed as a closed quantum system. The mean-field structure of the model allows an analytically tractable description of the MBLD transition using the forward-scattering approximation and repli...

Parisi's formal replica-symmetry-breaking (RSB) scheme for mean-field spin glasses has long been interpreted in terms of many pure states organized ultrametrically. However, the early version of this interpretation, as applied to the short-range Edwards-Anderson model, runs into problems because as shown by Newman and Stein (NS) it does not allow for chaotic size dependence, and predicts non-se...

Problem Statement: Data Grid architecture provides a scalable infrastructure for grid services in order to manage data files and their corresponding replicas that were distributed across the globe. The grid services are designed to support a variety of data grid applications (jobs) and projects. Replica selection is a high-level service that chooses a replica location from among many distribute...