R ENOVASCULAR hypertension is the most prevalent form of surgically curable high blood pressure. Nevertheless, controversy surrounds the screening of patients and the choice of appropriate diagnostic workup. In testing for renovascular hypertension, differences of opinion can be anticipated in view of several dilemmas. First, renovascular hypertension is a retrospective diagnosis. A technically...

BACKGROUND Noninvasive cost-effective screening of hypertensive patients for renovascular hypertension is a desirable approach to a rare disorder. Currently many patients are screened with angiography, which is both invasive and expensive. METHODS A MEDLINE search from 1985 through July 1994 using the key words "renovascular hypertension," "noninvasive," "screening" generated 16 references. W...

1. Saralasin and converting enzyme inhibitors SQ 20881 and captopril induced increases in plasma renin activity to greater than 14 ng h-1 ml-1 in 43 out of 44 patients with untreated renovascular hypertension when studied in the seated position and on normal sodium intake. This degree of response was absent in patients with normal-renin essential hypertension and present in only three out of 26...

Renovascular hypertension alters cardiac structure and function. Autophagy is activated during left ventricular hypertrophy and linked to adverse cardiac function. The angiotensin II receptor blocker, valsartan, lowers blood pressure and is cardioprotective, but whether it modulates autophagy in the myocardium is unclear. We hypothesized that valsartan would alleviate autophagy and improve left...

Angiotensin II increases and decreases arterial pressure by acting at angiotensin type 1 and type 2 receptors, respectively. Renovascular hypertensive rats exhibit a high level of activity of the peripheral and central renin-angiotensin system. Therefore, in the present study, we evaluated the effect of increasing the expression of angiotensin type 2 receptors in the solitary-vagal complex (nuc...

Renovascular disease includes renal artery stenosis, renovascular hypertension, and azotemic renovascular disease (ischemic nephropathy). Renovascular hypertension is defined as an elevated blood pressure caused by renal hypoperfusion, usually resulting from anatomic stenosis of the renal artery and activation of the renin-angiotensin system. It accounts for 1% to 2 % of all cases of hypertensi...

Aincrease in the vascular resistance of virtually every organ system is a wellknown characteristic of hypertension, as modeled by spontaneously hypertensive rats (SHR) and renovascular hypertensive rats. However, the most important issue may be where in the macrovasculature and microvasculature of a given organ the greatest increase in resistance occurs. The relevance of this issue can be consi...

background: hawthorn species decreases blood pressure and relaxes precontracted vessels. this study aimed at examining the antihypertensive effect and related mechanisms of hydroalcoholic extract of crataegus azarolus subspecies aronia fruit in rats with renovascular hypertension. methods: six groups of male sprague-dawley rats, each containing 6 to 8 rats, were studied. the groups comprised of...

This issue of Hypertension features an article by Imanishi and colleagues entitled "Aspirin Lowers Blood Pressure in Patients With Renovascular Hypertension." In their study, Imanishi and coworkers compared the effects of intravenously administered aspirin on arterial blood pressure, plasma renin activity in the renal veins and aorta, and plasma levels of prostaglandin E2 in the renal veins and...