196 cases with vesicoureteral reflux (VUR) from multiple centers were analysed to examine the relationship between VUR and reflux nephropathy. The high correlation (p less than 0.01) was observed between reflux and renal scarring. Even in cases in whom VUR was not demonstrated at the time of testing, renal scarring of various degrees was recognized, suggesting either co-existed hypoplastic kidn...

We examined for osteopontin (OPN) gene C/T polymorphism in 78 patients (53 girls) with vesicoureteric reflux, with or without renal scarring. The T allele frequency was associated with a significantly increased risk (26.4 fold) of renal scarring.

We determined urinary concentrations of alpha(1)-microglobulin and albumin in 155 patients with reflux nephropathy including 72 prepubertal (48 males and 24 females) and 83 postpubertal patients (43 males and 40 females) to elucidate the effect of age and gender in the progression of renal damage. Vesicoureteral reflux was resolved in all patients at least two years before enrollment into this ...

background: pyelonephritis can lead to renal scar.   objective : to evaluate the effects of betamethasone in preventing renal scarring in rat model of pyelonephritis.   methods : sixty three female sprague-dawley rats were divided into seven groups. group a was the control. mannose-sensitive e coli was directly inoculated into the left kidney exposed under general anesthesia in groups c–g. grou...