Background: Neurofibromatosis type I(NF1) is a neurocutaneous autosomal dominant disorder that has variable skin and neurological manifestation Multiple sclerosis (MS) not among these sequalae of Neurofibromatosis. Only 26 cases have been reported worldwide to the combination two diseases, none them from Saudi Arabia.We are presenting young lady who was diagnosed Sclerosis, Relapsing remitting ...

There is increasing evidence that neurofilament light chain (NF-L) can be considered as a biomarker for neuro-axonal damage. This polypeptide released into the cerebrospinal fluid (CSF) and blood, where it quantified. The concentration of NF-L elevated in patients with multiple sclerosis (MS) psychiatric disorders. We aimed to investigate levels CSF from treated MS relationship depression or an...

background and purpose: multiple sclerosis (ms) is believed to be an immune-mediated disorder that develops from an interaction of the individual's genetic and as yet unidentified environmental causes. the prevalence of auto-antibodies in multiple sclerosis patients and their clinical associations vary in various studies. the aim of this study was to determine serum auto antibodies in multiple ...

Background: Multiple sclerosis (MS) is an autoimmune disease that causes chronic inflammation of the central nervous system. MicroRNAs (miRNAs) are small non-coding RNAs 19–24 nucleotides long, which are differentially expressed in different tissues. The role of miRNAs in MS remains unclear. We assessed miR-10a transcript levels in MS patients during recurrence and two months after relapse. Ma...

background: we compared bone mineral density (bmd) in patients with relapsing-remitting multiple sclerosis (rrms) on interferon with that of patients with relapsing-remitting multiple sclerosis (rrms) who were not receiving interferon and healthy age- and sex-matched controls. methods: overall, 30 patients with rrms on interferon (treated patients), 30 patients with rrms but not receiving inter...

Laquinimod, a second-generation quinoline-3-carboxamide, is being developed by Active Biotech AB and Teva Pharmaceutical Industries Ltd for the treatment for relapsing-remitting multiple sclerosis (RRMS). Laquinimod has demonstrated significant activity in suppressing experimental autoimmune encephalomyelitis, an animal model of RRMS. In phase I and II clinical trials, the drug was well tolerat...

Recent research has characterized the anatomical connectivity of the cortico-cerebellar system - a large and important fibre system in the primate brain. Within this system, there are reciprocal projections between the prefrontal cortex and Crus II of the cerebellar cortex, which both play important roles in the acquisition and execution of cognitive skills. Here, we propose that this system al...

Background: Multiple sclerosis (MS) is categorized into four subtypes, including clinically-isolated syndrome (CIS), primary progressive multiple (PPMS), secondary (SPMS), and relapsing-remitting (RRMS). On the other hand, radiologically-isolated (RIS) characterized by imaging manifestations of MS rather than its clinical symptoms. Objectives: This study aimed to compare sociodemographic neuroi...

Multiple sclerosis (MS) is an inflammatory disease that affects the central nervous system. MicroRNAs (miRNAs) are small non-coding RNAs that are usually 18-24 nucleotides long, which may have a pivotal role in the expansion of many complex diseases. The objective of this study was to evaluate the transcript levels of miR-193b-3p and miR-376a-3p in relapsing-remitting multiple sclerosis (RRMS) ...

results of all the ms patients, 78 (95.1%) and 21 (25.6%) were positive for anti-vzv and vzv dna, respectively. statistical analysis of the pcr results showed a significant correlation between the abundance of vzv and ms disease (p < 0.001). however, there was no significant correlation between the abundance of anti-vzv antibodies and ms disease by the elisa method. conclusions these results su...