The aim of this study is to formulate a novel ophthalmic nanosuspension (ONS), an alternative carrier system to traditional colloidal carriers for controlled release (CR) of acyclovir (ACV). In the present study, ONS is employed to avoid some of major disadvantages of colloidal carriers systems such as instability in cul de sac and short half life by increasing efficiency of drug encapsulation ...

Objective(s) The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of theophylline using ethylcellulose as the retardant material with high entrapment efficiency. Materials and Methods Microspheres were prepared by water-in-oil-in-oil (W/O1/O2) emulsion-solvent diffusion (ESD). A mixed solvent system consisting of acetonitrile and dichloromet...

the purpose of this study was to prepare and characterize microspheres loaded by cyclosporine a(cya)-cyclodextrin (cd) complex. to achieve this goal, plga microspheres loaded by cya cd complex were prepared by multiple emulsificationsolvent evaporation methods.morphology, size, encapsulation efficiency and drug release from these microspheres were evaluated. microscopic evaluation of microspher...

background: sustained release delivery system can reduce the dosage frequency and maintain the therapeutic level of drugs for a longer time. biodegradable, biocompatible and thermosensitive chitosan-beta-glycerophosphate (c-gp) solutions can solidify at body temperature and maintain their physical integrity for a longer duration. objectives: to develop a novel delivery system based on the integ...

rivastigmine hydrogen tartrate (rht), one of the potential cholinesterase inhibitors, has received great attention as a new drug candidate for the treatment of alzheimer's disease. however, the bioavailability of rht from the conventional pharmaceutical forms is low because of the presence of the blood brain barrier. the main aim of the present study was to prepare positively charged eudragit r...

      The objective of the present study was to develop floating microspheres of cefpodoxime proxetil in order to achieve an extended retention in the upper GIT, which may result in enhanced absorption and thereby improved bioavailability. The microspheres were prepared by non-aqueous solvent evaporation method using polymers such as hydroxyl propyl methyl cellulose (HPMC K 15 M), ethyl cellulo...

the aim of the present work was to assess the feasibility of accononmc8-2ep/nf as a bioadhesive material for developing controlled release gastroretentive microsponges of loratadine. modified emulsion-solvent diffusion method was employed for the preparation of microsponges (f1-f9) based on 32 factorial design. the amount of ethyl cellulose (ec) and polyvinyl alcohol (pva) were selected as inde...

The gelatin/gum Arabic microcapsules encapsulating peppermint oil were prepared by complex coacervation using tannic acid as hardening agent. The effects of various parameters, including concentration of wall material, core material, tannic acid and tween80 were investigated on particle size and encapsulation efficiency. For statistical evaluation of the parameters, Taguchi method has been used...

objective(s): ketotifen fumarate (kf) is a selective and noncompetitive histamine antagonist (h1-receptor) that is used topically in the treatment of allergic conditions of rhinitis and conjunctivitis. the aim of this study was to formulate and improve an ophthalmic delivery system of kf.ocular nanoparticles were prepared with the objective of reducing the frequency of administration and obtain...