There is considerable evidence that genetic factors play a major role in the etiology of unipolar depression. Investigations into vulnerability genes for unipolar depression are underway and for more broadly defined depression-related traits, such as anxiety, neuroticism, and harm avoidance. This review discusses some of the core issues related to study design and molecular genetic methodology,...

OBJECTIVE The existing methods for identifying multiple rare variants underlying complex diseases in family samples are underpowered. Therefore, we aim to develop a new set-based method for an association study of dichotomous traits in family samples. METHODS We introduce a framework for testing the association of genetic variants with diseases in family samples based on a generalized linear ...

In our ongoing effort to identify genes influencing the biological pathways that underlie the metabolic disturbances associated with obesity, we performed genome-wide scanning in 2,209 individuals distributed over 507 Caucasian families to localize quantitative trait loci (QTLs), which affect variation of plasma lipids. Pedigree-based analysis using a quantitative trait variance component linka...

The discovery of ABC1 in 1994 stemmed from an effort to identify novel ATP-binding cassette (ABC) transporters in mouse macrophages, based on the selective amplification of consensus motifs in the nucleotide-binding domain (NBD) (Luciani et al., 1994; Savary et al., 1996, 1997). Among the new genes discovered, it soon became evident that ABC1 bore structural features distinct from those of know...

Thirty-eight male-to-female (M-to-F) transsexuals, 7 female-to-male (F-to-M) transsexuals, 135 nontranssexual men, and 225 nontranssexual women were assessed on the following: gender diagnosticity (GD) measures, which assessed male- vs. female-typical occupational and hobby preferences; instrumentality; expressiveness; self-ascribed masculinity; and self-ascribed femininity. M-to-F transsexuals...