calcification and inflammation are among the important cases of exudative age-related macular degeneration (e-armd). the aim of the present study was to elucidate if there is any relationship between serum osteoprotegerin (opg), soluble receptor activator of nuclear factor-kappa b ligand (rank-ligand) and e-armd. in a cross-sectional study, we compared 45 e-armd patients with 45 matched control...

PURPOSE To determine the cellular origin and the vascular endothelial growth factor (VEGF) immunoreactivity of the nonvascular stromal cells in surgically excised age-related macular degeneration (ARMD)-associated choroidal neovascular membranes (CNVMs). METHODS Immunohistochemical analysis was performed on frozen sections of eight surgically excised ARMD-related CNVMs. RESULTS Cytokeratin-...

BACKGROUND & OBJECTIVES Age related macular degeneration (ARMD) is a leading cause of blindness, particularly in persons above 60 yr of age. Homocysteine is implicated in many ocular diseases including ARMD. This study was undertaken to assess the status and relationship between plasma homocysteine, homocysteine - thiolactone, homocysteinylated protein and copper levels in patients with ARMD. ...

INTRODUCTION Age-related macular degeneration (ARMD) is a very common cause of vision loss especially in elderly patients living in developed countries. ARMD is caused by the accumulation of drusen in the macula, which is the most important part of the retina, and this process ends in serious irreversible visual impairment. Pigment epithelial detachment (PED) may be seen in all stages of ARMD a...

Objective: The objective of this study was to evaluate the association serum leptin levels with presence and severity age-related macular degeneration (AMD). Methods: A hospital-based case–control conducted on 84 patients (42 cases 42 controls) either sex complaining diminution vision aged 40 years above between August 2019 2021. Results: Mean level in 1.55±0.99 ng/mL control 2.11±0.88 (p<0....

Age-related macular degeneration (ARMD) may result from events initiated by reactive oxygen species. Blood samples from 18 patients with ARMD and 18 similarly aged controls were analysed for activities of important antioxidants. Blood glutathione reductase activity was lower in patients with ARMD compared with controls (p = 0.035). The activities of glutathione peroxidase (p = 0.18) and erythro...

OBJECTIVES We analysed different risk factors involved in the onset of both Alzheimer's disease (AD) and age-related macular degeneration (ARMD). The putative relation between both disorders was studied. METHODS We studied 57 subjects to determine the correlation between AD and ARMD. Thirty-three of the subjects suffered dementia (cases), whereas 24 of them (controls) did not. Firstly, anamne...

Macular dystrophies represent a heterogeneous group of disorders spanning a broad spectrum of clinical, histopathological, and laboratory findings. Despite this variability, funduscopic changes involving the macula and retinal pigment epithelium (RPE) and clinically significant loss of central or functional vision are characteristic of these disorders. As a group of diseases with a strong genet...

This study assesses the relation between age related macular degeneration (ARMD) and age, sex and occupation. It is designed as a retrospective study conducted on patients presenting to the Eye Polyclinic "Dr. L. Pavicević", Rijeka, Croatia, during the years 1995, 2000 and 2005, and included total of 6617 patients. The number of patients diagnosed with ARMD, their age and sex distribution, as w...

age related macular degeneration (amd) is the most common cause of visual impairment in the population above 64 years of age in developed countries. most cases of severe vision loss due to amd are caused by exudative changes in the macula. extensive research on amd has led to advances in its prophylaxis and treatment in recent years. photodynamic therapy (pdt) was developed in late 1990's ...