OBJECTIVES To find whether CSF analysis may differentiate between relapsing-remitting and secondary progressive multiple sclerosis. METHODS In 17 patients with relapsing-remitting and 16 patients with secondary progressive multiple sclerosis, all without current or recent relapses, albumin CSF: peripheral blood ratio, mononuclear cell number, CD4+, CD8+, and B1+ subsets, CD4+:CD8+ ratio, IgG,...

The spirochetal disease relapsing fever is caused by different Borrelia species. Relapsing fever is well recognized as an infection of the blood, but little is known about its predilection for the nervous system and the eyes. To investigate neurological and ocular involvement during relapsing fever, we reviewed the clinical manifestations, pathology, and treatment of relapsing fever of humans a...

Relapsing polychondritis is a multisystem disease characterized by recurrent inflammation of the cartilaginous tissue. Cardiovascular manifestations of relapsing polychondritis are rare but are the second most common cause of death in these patients. We report a case of relapsing polychondritis who underwent aortic valve replacement uneventfully but presented six months later with myocardial in...

Relapsing polychondritis affects the airway in half of all diagnosed patients. The traditional approach to the treatment of relapsing polychondritis in all sites is oral steroids and other immune-modulating drugs. We present a case of laryngeal relapsing polychondritis treated with local injections of steroid in the face of oral therapy failure. The novel approach is discussed and the disease p...

The original clinical classification of pancreatic inflammation, established at the Marseilles symposium in 1963, comprised acute pancreatitis, relapsing acute, chronic relapsing and chronic pancreatits (1) . Acute pancreatitis was characterized by clinical and pathologic reversibility, whereas chronic pancreatitis was characterized by permanent morphologic changes in the pancreas. Neither etio...

A major limitation of most animal models of autoimmune diseases is that they do not reproduce the chronic or relapsing-remitting pattern characteristic of many human autoimmune diseases. This problem has been overcome in our rat models of experimentally induced monophasic or relapsing-remitting autoimmune uveitis (EAU), which depend on the inducing antigen peptides from retinal S-Antigen (monop...

BACKGROUND Tick-borne relapsing fever spirochetes are maintained in endemic foci that involve a diversity of small mammals and argasid ticks in the genus Ornithodoros. Most epidemiological studies of tick-borne relapsing fever in West Africa caused by Borrelia crocidurae have been conducted in Senegal. The risk for humans to acquire relapsing fever in Mali is uncertain, as only a few human case...