Background: The development of a maternal immune response to fetal antigens and deficiency in regulatory T-cells (Tregs) may lead to preeclampsia. A plausible explanation for the reduced Treg cell function in women with preeclampsia is the presence of exhausted Treg cells which express CD279 or programmed cell death receptor-1 (PD-1), a negative regulatory molecule associated w...

Regulatory T cells (Tregs) play an important role in the maintenance of peripheral tolerance. Several molecules including TGF-beta have been linked to the function and differentiation of Tregs. In this study, we describe a unique population of T cells expressing a membrane bound form of TGF-beta, the latency-associated peptide (LAP), and having regulatory properties in human peripheral blood. T...

Diabetes type 1 is a chronic autoimmune disease in which insulin-producing cells are gradually destroyed by autoreactive T cells. Human regulatory cells play important role in controlling autoimmunity, and their qualitative or quantitative dysfunctions may result in ineffective suppression of autoreactive T cells. CD62L is a surface molecule that plays role in homing capabilities of Tregs, and ...

Multiple sclerosis (MS) is a complex neurological disease and its prevalence is about 2 million in the world. Neuroinflammation plays a key role in MS. Vitamins are essential nutrients that have effective role on immune system including activation of lymphocyte and differentiation of T-helper cell. Vitamin D is a micronutrient that is effective on immune function. Deficiently of Vitamin D is a ...

www.onk.ns.ac.rs/Archive Vol 20, No. 1–2, July 2012 T-regulatory cells: key players in tumor immune escape and angiogenesis T-regulatory cells (Tregs) are found infiltrating tumors in a vast array of tumor types, and tumor-infiltrating Tregs are often associated with a poor clinical outcome. Tregs are potent immunosuppressive cells of the immune system that promote progression of cancer through...

The T-cell receptor (TCR) is required for maturation and function of regulatory T cells (Tregs), but the ligand specificities of Tregs outside the context of transgenic TCRs are largely unknown. Using peptide-MHC tetramers, we isolated rare specific Foxp3+ cells directly ex vivo from adult peripheral blood and defined their frequency and phenotype. We find that a proportion of circulating Tregs...

Although B cells are traditionally known for their role in propagating proinflammatory immune responses, their immunosuppressive effects have only recently begun to be appreciated. How these regulatory B cells (Bregs) suppress the immune response remains to be worked out in detail. In this article, we show that Bregs can induce the formation of conventional FoxP3+ regulatory T cells (Tregs), as...

Objective: Dendritic cells (DCs) play an important role in regulating T cell-mediated immune responses; however, the mechanisms of DC-mediated immune responses have not been fully elucidated. Regulatory T cells (Tregs) including CD4+ and CD8+ Tregs play an essential role in induction of immune tolerance in vivo. It is unclear how DCs regulate development of Tregs. Our objective is to observe wh...

Abstract Regulatory T cells (Tregs) exert immunosuppressive functions and hamper anti-tumor immune responses in the tumor microenvironment. Understanding heterogeneity of intratumoral Tregs, how it changes with progression, will provide clues regarding novel target molecules Treg-directed therapies. Here we characterized phenotypes suppressive function Tregs from tissues 42 patients renal cell ...

multiple sclerosis (ms) is a complex neurological disease and its prevalence is about 2 million in the world. neuroinflammation plays a key role in ms. vitamins are essential nutrients that have effective role on immune system including activation of lymphocyte and differentiation of t-helper cell. vitamin d is a micronutrient that is effective on immune function. deficiently of vitamin d is a ...