A recent Letter by Eckfeldt et al. (1) recalled some of our unpublished findings of a few years ago, showing the effect of sodium azide on continuous-flow (SMA 12/60) measurements (Table 1). The azide interference with total bilirubin determinations they reported can be also be seen in our results, although not conspicuously. As can be seen in Table 1, measurements other than bili-. rubin may b...

CLINICAL CHEMISTRY, Vol. 24, No. 4, 1978 731 variation of 5.7% was obtained at a level of 11 nmol/ml per hour. The figure shows the levels of erythrocyte uroporphyrinogen I synthase detected in three generations of a family with AlP. The level of activity of the proband (W.1) was just within the statistical reference range. Her father (ffl.I) and daughter (V.3) had values for actiVity that were...

2. Ambre, J. J., and Fischer, L. J., Identification and activity of the hydroxy metabolite which accumulates in the plasma of humans intoxicated with glutethimide. Drug Metab. Disposition (in press). 3. Gold, M., Tassoni, E., Etzl, M., and Mathew, G., Concentration of glutethimide and associated compounds in human serum and cerebrospinal fluid after drug overdose. Clin. Chem. 20, 195 (1974). 4....

Recently we had occasion to assay for lactate dehydrogenase (EC 1.1.1.27) in the presence of a large amount of potassium cyanide and were surprised to see a 10-fold increase in the enzyme activity when we used a method that depends on the measurement of NADH. At first we thought that we had made a significant observation.You can imagine our disappointment when we found that a control consisting...

148 CliNICAL CHEMISTRY. Vol. 23, No. 1, 1977 aniline the regression equations obtained were as follows: y = 0.988x + 0.695, r = 1.00, t = 0.358,P <0.8>0.7, n = 12; y = 0.976x+ 0.799, r = 1.00, t = 1.71,P <0.2 > 0.1, n = 20; and y = 0.978x+ 0.901, r = 1.00, t = 1.71,P < 0.1 >0.05,n32. In the presence of 4-nitroaniline, valueswere y = 0.986x + 2.50,r = 1.00, t = -2.0, P = <0.1 > 0.05, n = 12; y =...

The National Academy of Sciences-National Research Council Twin Registry (NAS-NRC Twin Registry) is a comprehensive registry of White male twin pairs born in the USA between 1917 and 1927, both of the twins having served in the military. The purpose was medical research and ultimately improved clinical care. The cohort was assembled in the early 1960s with identification of approximately 16,000...

AIM In 2008, the Danish National Chronic Lymphocytic Leukemia Registry was founded within the Danish National Hematology Database. The primary aim of the registry is to assure quality of diagnosis and care of patients with chronic lymphocytic leukemia (CLL) in Denmark. Secondarily, to evaluate adherence to national guidelines and to provide source data for research purposes. STUDY POPULATION ...

OBJECTIVE The regulation of surgical implants is vital to patient safety, and there is an international drive to establish registries for all implants. Hearing loss is an area of unmet need, and industry is targeting this field with a growing range of surgically implanted hearing devices. Currently, there is no comprehensive UK registry capturing data on these devices; in its absence, it is dif...