نتایج جستجو برای: refractory anemia
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abstract background iron-deficiency anemia is a widespread public health problem with major consequences for human health especially, children. however, in a fraction of patients an underlying cause is never found during routine investigation. recent studies have suggested an association between helicobacter pylori (h. pylori) infection and iron-deficiency anemia. case presentation here is repo...
Iron refractory iron deficiency anemia is a hereditary recessive anemia due to a defect in the TMPRSS6 gene encoding Matriptase-2. This protein is a transmembrane serine protease that plays an essential role in down-regulating hepcidin, the key regulator of iron homeostasis. Hallmarks of this disease are microcytic hypochromic anemia, low transferrin saturation and normal/high serum hepcidin va...
Refractory cytopenia of childhood is the most common type of childhood myelodysplastic syndrome. Because the majority of children with refractory cytopenia have a normal karyotype and a hypocellular bone marrow, differentiating refractory cytopenia from the immune-mediated bone marrow failure syndrome (very) severe aplastic anemia can be challenging. Flow cytometric immunophenotyping of bone ma...
BACKGROUND Ghosal Type Hematodiaphyseal Dysplasia is an autosomal recessive disorder characterized by refractory anemia and diaphyseal bone dysplasia. CASE CHARACTERISTICS A 3 y 9 mo-old male child presented with progressive anemia and bowing of thighs. Child was found to have a previously reported homozygous point mutation c.1238G>A, (p.Arg413Glu) in Exon 16 of TBXAS1 gene. OUTCOME Low dos...
Clinics and pathology Disease Myeloid disorders: Myelodysplastic syndrome ( MDS ) type refractory anemia (RA) (Wlodarska et al., 1995) and refractory anemia with excess blasts (RAEB) (Struski et al., 2008). Philadelphia chromosome positive chronic myeloid leukemia (CML) in transformation (Aguiar et al., 1997). Etiology Only 3 cases so far; 77-year old male (MDS-RA) and 71-year old female (MDS-R...
Background: Helicobacter pylori has caused gastritis leading to bleeding and iron deficiency anemia. H-pylori eradication results in better response oral treatment. Aim: To determine the frequency of improvement refractory anemia after successful H-pylori. Study design: Descriptive, case series. Methodology: Patients (n=89) anemia, 15-55 years either gender were included. After this taking rele...
The presence of preleukemic state as a syndromepreceding cancer or a precancerous phase has been knownfor manyyears. With the establishment of diagnostic criteria and treatment for hematological diseases, particularly for leukemia as well as anemia, and with the development of the concept of other types of hematologic abnormalities for standardizing such criteria and treatment, the preleukemic ...
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