Recent studies have demonstrated resting-state abnormalities in midline regions in vegetative state/unresponsive wakefulness syndrome and minimally conscious state patients. However, the functional implications of these resting-state abnormalities remain unclear. Recent findings in healthy subjects have revealed a close overlap between the neural substrate of self-referential processing and the...

Aphasics, brain-damaged patients with no language deficit, neurologically intact elderly subjects, and university undergraduates matched pictures to sentences having compelling tacit implications (e.g., the sentence The fox grabs the hen strongly invites one to assume that the fox will eat the hen). All groups made, for the same sentences, qualitatively similar referential errors consisting in ...

Major depression is associated with a bias toward negative emotional processing and increased self-focus, i.e., the process by which one engages in self-referential processing. The increased self-focus in depression is suggested to be of a persistent, repetitive and self-critical nature, and is conceptualized as ruminative brooding. The role of the medial prefrontal cortex in self-referential p...

BACKGROUND It has been demonstrated that negatively distorted self-referential processing, in which individuals evaluate one's own self, is a pathogenic mechanism in subthreshold depression that has a considerable impact on the quality of life and carries an elevated risk of developing major depression. Behavioural activation (BA) is an effective intervention for depression, including subthresh...

BACKGROUND Referential delusions are the most common symptom of schizophrenia and offer an opportunity to examine the neural correlates of delusions because they occur in discrete episodes that can be studied in the scanner. The cortical midline structures (CMS) and subcortical regions, including the amygdala and striatum, are linked with self-reference in healthy adults. Less is known about th...

BACKGROUND Self-referential processing (i.e. linking internal and external stimuli to one's own self) has received scant attention thus far in schizophrenia. This type of processing is a key component of social cognition and thought to be important for adaptive social functioning. Memory studies in healthy subjects have shown that stimuli processed with reference to the self are better remember...

Using fMRI, we studied the neural correlates of self-referential processing by comparing BOLD signal changes during self and mother conditions of a self-reference effect (SRE) task. Conjunction analysis of these two conditions showed several common areas of significant activation, including the medial aspects of the superior frontal gyri, left inferior frontal gyrus, bilateral temporal poles, l...

Recent neuroimaging work has observed activity in cortical midline structures (CMS) such as medial prefrontal and posterior cingulate cortices during self-referential processing. Moreover, items rated as self-relevant produce increased activity in these regions relative to items that are deemed not self-relevant. A common thread among previous reports has been reliance on experimental tasks tha...