PURPOSES To evaluate the effect of subconjunctival bevacizumab in an experimental model of neovascularization in rabbit cornea. Determine its effect on vessels extension, inflammation, epithelialization of the cornea and whether the evaluation method used is appropriate to compare neovascular models. METHODS Experimental, prospective, randomized, blinded study in twenty rabbits subjected to c...

OBJECTIVES To compare topical interleukin 1 receptor antagonist (IL-1ra) to steroid treatment following photorefractive keratectomy (PRK) in rabbit eyes. METHODS Our study is a randomized, investigator-masked study that was approved by the Institutional Animal Care and Use Committee. Following standard PRK, 48 eyes of 24 rabbits were divided into 5 arms: 4 treatment arms and 1 control arm. Th...

Wounds and wound healing have always been one of the most important subjects that experimental researches were dedicated to. Simvastatin has been used for long as a common lipid lowering agent which was reported to have some pleiotropic effects such as antioxidation, anti-inflammation and immunomodulation. In this study we aimed to determine the effect of simvastatin on wound healing process in...

Wounds and wound healing have always been one of the most important subjects that experimental researches were dedicated to. Simvastatin has been used for long as a common lipid lowering agent which was reported to have some pleiotropic effects such as antioxidation, anti-inflammation and immunomodulation. In this study we aimed to determine the effect of simvastatin on wound healing process in...

Sebaceous glands (SG) produce and secrete lipids onto the skin surface to protect it from dehydration harmful pathogens. Peroxisome proliferator-activated receptor-gamma (PPARg) is a member of nuclear receptor family ligand-activated transcription factors that critical for SG formation. Here, we report PPARg initially expressed within transitional basal cells in progenitor compartment. Lineage ...

Background: To evaluate the therapeutic effects of corneal collagen cross-linking CXL as an adjuvant to standard antimicrobial agents in treatment bacterial keratitis when compared with alone. Methods: This prospective comparative interventional study included 20 eyes patients clinical and laboratory evidence who attended Outpatient Cornea Unit, Ophthalmology Department, Faculty Medicine Assiut...

Exosomes have shown promising potential as a therapeutic approach for wound healing. Nevertheless, the translation from experimental studies to commercially available treatments is still lacking. To assess current state of research in this field, systematic review was performed involving conducted and published over past five years. A PubMed search English-language, full-text papers 2018 June 2...