Crossbridge models of muscle contraction based on biochemical studies predict that there may be a relationship between the rate-limiting step in the actomyosin ATPase cycle in vitro and the rate of force development in vivo. In the present study, we measured the rate of force redevelopment in skinned rabbit muscle fibers following unloaded isotonic shortening and a rapid restretch. For comparis...

PURPOSE Bleomycin electrochemotherapy has been successfully used in preclinical studies and clinical trials for treating squamous cell carcinoma (SCC) and adenocarcinoma; however, it is not effective for treating recurrent tumors or metastatic tumors, or for preventing tumor redevelopment. In this study, we explore the coadministration of bleomycin and interleukin-12 (IL-12) followed by electro...

Acknowledgements I am extremely grateful for the support and guidance provided by my advisor, Dr. Erica Field, in talking through data collection challenges and my data analysis and empirical strategy. I would like to thank my advisor, Dr. Michelle Connolly, who provided immensely valuable feedback over the last year for the research study. Without Dr. Connolly's meticulous support, this thesis...

BACKGROUND Residents of many cities lack affordable, quality housing. Economically disadvantaged neighborhoods often have high rates of poverty and crime, few institutions that enhance the quality of its residents' lives, and unsafe environments for walking and other physical activity. Deteriorating housing contributes to asthma-related illness. We describe the redevelopment of High Point, a We...

Property asset management is keenly influenced by the market rental price for the services and asset quality. Renovation is conceived as a form of redevelopment that returns the property back to its pristine state after experiencing quality deterioration. We formulate a two-factor renovation model under rental price and quality uncertainty and a fixed investment cost. The renovation policy is d...

Abstract Under the scheme of Japanese City Renewal Law (JCRL), the cost of urban redevelopment project has been financed by the revenue from selling the reservation floor secured beforehand in the redeveloped building. Since the outcome of whether or not the reservation floor can be sold is unforeseeable, entities for redevelopment are faced with the risk for project financing. Traditional risk...

This study examines policies and practices related to the conservation of historic districts in China, where urban conservation has become a significant concern and pressing issue in the present era of economic reform and urban redevelopment. In addition to illustrating the evolution of approaches to historic district conservation, the study reveals some of the social and political problems tha...

Due to the diversity of resources and different personalized management requirements, Cloud management is faced with great challenges in complexity and difficulty. For constructing a management system to satisfy a specific requirement, a redevelopment solution based on existing system is usually more practicable than developing the system from scratch. However, the difficulty and workload of re...

London's Royal Opera House has undertaken a much-needed redevelopment. The management of the operation has been problematic, bringing the House close to insolvency, and causing the resignation of many senior staff. This paper summarises these events, and earlier papers analysing them using systemic methods. It examines the organisation's structure using Beer's Viable Systems Model. The manageme...