In the UK, perioperative non-steroidal anti-inflammatory drugs are commonly administered via the rectal route even though suppositories are unpopular with patients. This prospective, randomised, double-blind study compares the analgesic effectiveness of diclofenac 100 mg given either orally or rectally to 42 ASA grades 1 and 2 patients scheduled to undergo day-case laparoscopic sterilization by...

OBJECTIVE To evaluate the efficacy of different antipyretic agents and their highest recommended doses for preventing febrile seizures. DESIGN Randomized, placebo-controlled, double-blind trial. SETTING Five hospitals, each working as the only pediatric hospital in its region. PARTICIPANTS A total of 231 children who experienced their first febrile seizure between January 1, 1997, and Dec...

OBJECTIVE To compare the effects of intrauterine lidocaine, intrauterine lidocaine plus rectal diclofenac, and a placebo on analgesia and to determine the satisfaction of patients and surgeons in cases of endometrial biopsy. METHODS The double-blind, randomised, placebo-controlled study was conducted in the Department of Obstetrics and Gynaecology of the Ondokuz Mayis University, Samsun,Turke...

The article by Mogadam et al. (1) regarding the comparison of analgesic effect of gabapentin and diclofenac on pain after tonsillectomy was interesting, as it explained the comparison of analgesic efficacy results of preoperative gabapentin and diclofenac administration on postoperative pain in tonsillectomy. However, it is noted that one of the main factors which influences the rate of drug ab...

BACKGROUND AND STUDY AIMS Rectal nonsteroidal anti-inflammatory drugs have been shown to reduce the incidence of postendoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). The aim of this study was to determine whether intramuscular diclofenac reduces the risk of PEP. PATIENTS AND METHODS Patients who underwent ERCP were randomized to receive either 90 mg of diclofenac or p...

BACKGROUND Tonsillectomy is a common procedure causing considerable postoperative pain. Postoperative pain intensity of 60 - 70 in the scale of visual analog scale (VAS) has been reported up to 3 - 4 days which could continue until 11 days after the surgery. OBJECTIVES The current study aimed to compare the analgesic effect of gabapentin and diclofenac on pain after tonsillectomy with the con...