نتایج جستجو برای: recombinant vaccine
تعداد نتایج: 211060 فیلتر نتایج به سال:
Background and purpose: The most common cause of diarrhea is Shigella and no vaccine has been found so far. IpaD and STxB proteins (B subunit of Shiga toxin) play an important role in invasion, infection and pathogenesis caused by Shigella. To evaluate the immunogenicity of each of the proteins IpaD and STxB can using of two animal models mice and guinea pigs and could be determined role of eac...
diphtheria is a fatal disease caused by exotoxin of corynebacterium diphtheria . this toxin consists of two chains, catalytic chain (a) and binding (b) chain. by binding chain (b), the toxin binds to its receptor on numerous body cells such as myocardial, kidney and peripheral nerve cells. after entering, catalytic chain (a) inhibits protein synthesis and finally can cause cell dea...
objective: preventing communicable diseases in the armed forces (af) of a country is considered as a national interest and has a great importance. there are limited data on the efficacy of vaccination of the navy personnel. this study was designed to evaluate both the safety and the immunogenicity of a recombinant hepatitis b (hb) vaccine made by pasteur institute of iran (ipi-rhb), in this tar...
Recombinant proteins are tending to be the most favorable vaccine-candidates against botulism. Recombinant Carboxy-terminal of botulinum neurotoxin serotype E (rBoNT/E-HCC) has been introduced as an efficient vaccine against botulism type E. In this report, we made an effort to investigate the effect of different pH on protein structure to assess if rBoNT/E-HCC could be used as a vaccine for or...
results primary, secondary, and 3d structure of cchfv gn were obtained and pcr reaction with m13 forward and reverse primers confirmed the generation of recombinant bacmid dna harboring gn coding region under polyhedron promoter. conclusions characterization of the detailed structure of cchfv gn by bioinformatics software provides the basis for development of new experiments and construction of...
Foot-and-mouth disease (FMD) is an extremely infectious and occasionally fatal viral disease with a rapid onset and a short course that affects cloven-hoofed animals and results in considerable financial losses. For this reason, availability of more reliable and efficient vaccines against Foot-and-mouth disease virus (FMDV) is felt as a necessity. The purpose of this study is to develop a ...
Objective(s): Despite treatment with antibiotics and vaccination with BCG, tuberculosis (TB) is still considered as one of the most important public health problems in the world. Therefore, designing and producing a more effective vaccine against TB seems urgently. In this study, immunogenicity of a fusion protein which consisting or comprising CFP-10 from Mycobacterium tuberculosis and the Fc-...
recombinant proteins are tending to be the most favorable vaccine-candidates against botulism. recombinant carboxy-terminal of botulinum neurotoxin serotype e (rbont/e-hcc) has been introduced as an efficient vaccine against botulism type e. in this report, we made an effort to investigate the effect of different ph on protein structure to assess if rbont/e-hcc could be used as a vaccine for or...
background: mycobacterium tuberculosis is the causative agent of tuberculosis (tb). bacille calmette-guerin (bcg) vaccine, is not effective in adults, therefore, many efforts have been made to produce an effective adult tb vaccine. the aim of this study was to develop a new tuberculosis dna vaccine candidate encoding a recombinant hspx-ppe44-esxv fusion antigen of m. tuberculosis. methods: a fu...
Background and purpose: Vaccination is the most effeetive method of prophylaxy in high risk group of hepatitis B. Some individuals faile to respond to triple doses of vaccine which is potentially dangerous. Therefore, immunogenecity of triple doses recombinant hepatitis B vaccine was evaluated in a high risk group (medical sciences students). Materials and Methods: 193 healthy medical scie...
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