نتایج جستجو برای: recombinant therapeutic human protein

تعداد نتایج: 2754232  

A major problem in the formulation of therapeutic proteins is the irreversible protein aggregation. Recombinant human interferon alpha2b (rhIFN2b) has poor stability and undergoes physical degradation. The aim of this study was to investigate the effect of solution conditions on the heat-induced aggregation of rhIFNα2b. The protein was incubated for 1 h at 40°C–70°C and for up to 240 h at 50C...

A major problem in the formulation of therapeutic proteins is the irreversible protein aggregation. Recombinant human interferon alpha2b (rhIFN2b) has poor stability and undergoes physical degradation. The aim of this study was to investigate the effect of solution conditions on the heat-induced aggregation of rhIFNα2b. The protein was incubated for 1 h at 40°C–70°C and for up to 240 h at 50C...

Journal: :molecular and biochemical diagnosis (journal) 2014
nadir alipour nasrin gaini

background: erythropoietin (epo) is a glycoprotein hormone function to regulate the production of red blood cells. deficiency of epo is known to cause anemia in chronically infected renal patients and they require regular blood transfusion. availability of recombinant epo has eliminated the need for blood transfusion and now it is extensively used for the treatment of anemia. glycosylation of e...

Journal: :reports of biochemistry and molecular biology 0
kadijeh tati shiraz institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, iran - department of immunology, school of medicine, shiraz university of medical sciences, shiraz, iran mahsa yazdanpanah-samani shiraz institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, iran amin ramezani shiraz institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, iran - department of medical biotechnology, school of advanced medical sciences and technologies, shiraz university of medical sciences, shiraz, iran elham mahmoudi maymand shiraz institute for cancer research, school of medicine, shiraz university of medical sciences, shiraz, iran abbas ghaderi tel: +98 71 32303687; fax: +98 71 71 32304952

background: cd52 is a small glycoprotein with a gpi anchor at its c-terminus. cd52 is expressed by normal and malignant t and b lymphocytes and monocytes. there are detectable amounts of soluble cd52 in plasma of patients with cll and could be used as a tumor marker. although the biological function of cd52 is unknown but it seems that cd52 may be involved in migration and activation of t-cells...

  Objective(s): Streptokinase (SKa) is an antigenic protein which is secreted by Streptococcus pyogenes. Streptokinase induces inflammation by complement activation, which may play a role in post infectious diseases. In the present study, recombinant streptokinase from S. pyogenes was produced and showed that recombinant SKa protein was recognized by infected human sera using Western blot analy...

Journal: :international journal of nano dimension 0
s. imani department and research center of biology, ihu, tehran, iran. a.m. zand department and research center of biology, ihu, tehran, iran. m. saadati biotechnology research center, baqiyatallah university of medical sciences, tehran, iran. h. honnari department and research center of biology, ihu, tehran, iran. b. maddah department of chemistry, ihu, tehran, iran.

recombinant protein purification is a kind of sensitive and expensive method in genetics engineering. genetic manipulation leads to the expression of various proteins; it should be isolated with high purity finally. differed methods for protein purification are categorized, based on cast, quality, easy work and side effect of protein. in this article, we are investigating his his-tag protein pu...

Ali Hatef Salmanian Ghasem Mosayebi, Hamid Abtahi, Maryam Baazm, Mohsen Khaki, Neda Molaee Saeed Babaei

Objective(s): Vascular endothelial growth factor (VEGF) is one of the most effective proteins in angiogenesis, mesenchymal stem cells (MSCs) differentiation and wound healing. These abilities are therapeutic potential of VEGF in diabetic retinopathy, nephropathy and other tissue damage circumstances. In this study, recombinant VEGF was produced in Escherichia coli (E. coli) system and then biol...

Ali Khodadadi Amir Jalali Hamid Galehdari Mohammad Shafeei Nahid Shahbazian Parichehr Darabi Saeed Reza Khatami

Background: Leukemia inhibitor factor (LIF) is a very important pleiotropic cytokine which belongs to interleukin-6 (IL-6) family. LIF exerts multiple effects on different types of cells and tissues with numerous regulatory effects in vivo and in vitro. It is a lymphoid factor, which performs a number of activities including cholinergic neuron differentia‌tion, contro...

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