Although Plasmodium vivax is a leading cause of malaria around the world, only a handful of vivax antigens are being studied for vaccine development. Here, we investigated genetic signatures of selection and geospatial genetic diversity of two leading vivax vaccine antigens--Plasmodium vivax merozoite surface protein 1 (pvmsp-1) and Plasmodium vivax circumsporozoite protein (pvcsp). Using scala...

Abstract Plasmodium vivax is the most common human malaria parasite in Asian countries including Pakistan. Present study was designed to explore genetic diversity of plasmodium genotypes based on Pvmsp-3α and Pvmsp-3βgenes using allelic specific nested PCR RFLP assays markers from field isolates district Mardan, Blood samples 200 P. malarial patients were collected after taking their written in...

Plasmodium merozoites are covered with a palisade layer of proteins that are arranged as organized bundles or appear as protruding spikes by electron microscopy. Here we present a third Plasmodium vivax merozoite surface protein, PvMSP-3, which is associated with but not anchored in the merozoite membrane. Serum from a P. vivax immune squirrel monkey was used to screen a lambdagt11 P. vivax gen...

The development of an effective immune response can help decrease mortality from malaria and its clinical symptoms. However, this mechanism is complex and has significant inter-individual variation, most likely owing to the genetic contribution of the human host. Therefore, this study aimed to investigate the influence of polymorphisms in genes involved in the costimulation of B-lymphocytes in ...

background: plasmodium vivax malaria accounts for approximately 88% of malaria cases in iran. there is limited in­formation on genetic diversity of p. vivax in the country and a need to develop and apply an effective vaccine against the dis­ease is necessary. among many potential candidates, msp -3β gene is promising target. this study was designed and car­ried out to determine the variation of...

background: approximately 85-90% of malaria infections in iran are attributed to plasmodium vivax , while little is known about the genetic of the parasite and its strain types in this region. this study was designed and performed for describing genetic characteristics of plasmodium vivax population of iran based on the merozoite surface protein-3α gene sequence. methods: through a descriptive ...

Abstract Background Plasmodium vivax contributes to over 70% malaria burden in Pakistan, but limited data exists on various aspects including genetic diversity of the parasite as compared other parts world. Since information about P. assists understand population dynamics parasite, current study was designed divergence Pakistan using circumsporozoite protein (pvcsp) and merozoite surface protei...

Plasmodium vivax merozoite surface protein 1 (PvMSP-1) has been considered a major candidate for the development of an antimalaria vaccine, but the molecule exhibits antigenic diversity among isolates. The extent of genetic polymorphism in the region between interspecies conserved blocks 4 and 5 (ICB4 and ICB5) of the PvMSP-1 gene was analyzed for 30 Korean isolates. Two genotypes, SK-A and SK-...

background: the worldwide distribution of p. vivax has expanded significantly and the number of reported cases has been on the rise. approximately 88% of malaria cases in iran are caused by plasmodium vivax , and in order to management of the disease, understanding the population genetic structure of the parasite is necessary for designing and applying drugs and vaccines. among many potential c...

BACKGROUND A successful malaria elimination program calls for enough attention to parasite carriers, especially asymptomatic malaria, as well as the diagnosis and treatment of clinical cases. Asymptomatic malaria is an infection that patients do not show any symptom; thus, these patients play critical role in the concept of an elimination program. The current investigation was conducted to eval...