Recipient disparity for the HA-1 minor histocompatibility antigen has been associated with acute graft-versus-host disease (GVHD) after marrow transplantation from an HLA-identical sibling.1 We have also shown a trend toward higher risk of grades II to IV acute GVHD in recipients mismatched for HA-1 among a selected HLA-A2–positive population (P 5 .08), but the odds ratio (2.1) was lower than t...

The role of HLA-DPB1 disparity in the development of acute graft-versus-host disease (GVHD) following unrelated donor (URD) marrow transplantation is unknown. We studied 129 patients who underwent marrow transplantation from HLA-A, -B, -DRB, and -DQB matched URDs to determine whether matching for HLA-DPB1 alleles significantly decreased the risk of developing acute GVHD. HLA-DPB1 alleles were d...

One hundred twelve patients less than 36 years old received marrow grafts from unrelated donors as treatment for hematologic malignancy. Seventy donor/recipient pairs were phenotypically identical for HLA-A, -B, and -D, while 42 had a "minor" disparity at one HLA locus. There was an increase in the risk of acute graft-versus-host disease (GVHD) in patients receiving HLA-partially matched grafts...

Marrow graft failure observed in association with histocompatibility differences between donor and recipient is often attributed to rejection mediated by host-derived cytolytic T lymphocytes. The data presented in this report indicate that persistent host antibodies specific for donor antigen may also mediate graft failure, either by antibody-dependent cell-mediated cytotoxicity (ADCC), or comp...

In this paper, a new approach for optimizing disparity candidates space is proposed for the solution of dense stereo matching problem. The main objectives of this approachare the reduction of average number of disparity candidates per pixel with low computational cost and high assurance of retaining the correct answer. These can be realized due to the effective use of multiple radial windows, i...

Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare complication of blood transfusion. The clinicolaboratory features of TA-GVHD and the relative contributions of recipient and component factors remain poorly understood. We conducted a systematic review of TA-GVHD reports. The HLA relationship between donor and recipient was classified as D = 0 when no donor antigens were forei...

purpose: to determine the long-term visual outcomes and complications of penetrating keratoplasty (pk) performed for keratoconus. methods: hospital records of patients with keratoconus who underwent pk at the ophthalmology center of shaheed sadoughi, yazd, iran, during 1992-2003 were reviewed. we studied records of 84 pk procedures in 72 keratoconus patients. data including best corrected visua...

Cytomegalovirus (CMV) infection during the transient immunodeficiency after bone marrow transplantation (BMT) develops into disease unless antiviral CD8 T cells are restored in due course. Histoincompatibility between donor and recipient is associated with increased risk. Complications may include a rejection response against the foreign major histocompatibility complex (MHC) antigens and a lac...

BACKGROUND AND OBJECTIVES Detecting differences in the variable number of tandem repeats (VNTR) between a recipient and a donor has already been used to monitor the degree of chimerism after allogeneic stem cell transplantation (SCT). Alongside major histocompatibility complex disparity, the disparity of various polymorphous proteins encoded by several genes may play a critical role in the path...