the vasopressin v2 receptor belongs to the large family of the g-protein coupled receptors and is responsible for the antidiuretic effect of the neurohypophyseal hormone arginine vasopressin (avp). based on bioinformatic studies it seems that ala300 and asp297 of the v2 vasopressin receptor (v2r) are involved in receptor binding. ala300glu mutation resulted in lower energy while asp297tyr mutat...

Transforming growth factor beta (TGFβ1, β2, and β3) are 25 kDa disulfide-linked homodimers that regulate many aspects of cellular functions, consist of proliferation, differentiation, adhesion and extracellular matrix formation. TGFβs mediate their biological activities by binding of growth factor ligand to two related, functionally distinct, single-pass transmembrane receptor kinases, known as...

BACKGROUND Prior research has identified several components of the innate immune system that may play a significant role in chronic rhinosinusitis (CRS), but the role of innate immunity in patients with CRS is poorly understood. The objective of this study was to determine differential expression of innate immunity genes in the mucosa of patients with CRS with nasal polyposis (CRSwNP) and CRS w...

abstract introduction: there is limited knowledge available on the metabolism of glucose in the brain, an insulin insensitive organ. insulin receptors hybridize with insulin like growth factor receptor (igf-i) to transduce the signals in different areas of the brain. in this article we aimed at investigating whether the expression of igf-i receptor and igf-i binding proteins (igfbp1) is changed...

Context. Asteroid (22) Kalliope is the second largest M-type asteroid in main belt and orbited by a satellite, Linus. Whereas mass of already well constrained thanks to presence moon, its volume still poorly known, leading uncertainties on bulk density internal structure. Aims. We aim refine shape thus diameter density, as orbit moon better constrain mass, hence Methods. acquired disk-resolved ...