نتایج جستجو برای: receptor pharmacology
تعداد نتایج: 615995 فیلتر نتایج به سال:
A Retraction of the Original research article “Astragali Radix Isoflavones Synergistically Alleviate Cerebral Ischemia and Reperfusion Injury Via Activating Estrogen Receptor-PI3K-Akt Signaling Pathway”Gu Y, Chen X, Fu S, Liu W, Wang Q, K-J Shen J (2021) Astragali Receptor□PI3K-Akt Pathway. Front. Pharmacol. 12:533028. doi: 10.3389/fphar.2021.533028"Following publication, concerns were raised r...
BACKGROUND Cannabinoid 1 (CB1) receptor antagonists exhibit pharmacological properties favorable for the treatment of obesity and other related metabolic disorders. CE-178253 (1-[7-(2-Chlorophenyl)-8-(4-chlorophenyl)-2-methylpyrazolo[1,5-a]-[1,3,5]triazin-4-yl]-3-ethylaminoazetidine-3-carboxylic acid hydrochloride) is a recently discovered selective centrally-acting CB1 receptor antagonist. Des...
Label-free biosensors offer integrated, kinetic and multi-parametric measures of receptor biology and ligand pharmacology in whole cells. Being highly sensitive and pathway-unbiased, label-free receptor assays can be used to probe the systems cell biology including pleiotropic signaling of receptors, and to characterize the functional selectivity and phenotypic pharmacology of ligand molecules....
conclusions anesthesiologists need to be aware of dextromethorphan’s clinical pharmacology because recreational abuse of the drug has become increasingly common in adolescents and young adults. case presentation a 30-year-old man with a history of a nasal fracture was scheduled to undergo an elective septorhinoplasty. he reported daily consumption of large quantities (1440 to 1800 mg) of dextro...
Study on the mechanism of Erzhi Pill in the treatment of breast cancer based on network pharmacology
Objective: To explore the possible mechanism of Erzhi Pill in treatment breast cancer based on network pharmacology. Methods: Through systematic pharmacology database and analysis platform Traditional Chinese medicine (TCMSP) literature review, candidate active ingredients corresponding targets were retrieved collected. The UniProt Human Genome Annotation Database (Genecards) used to compare re...
Nuclear receptor pharmacology has, to a certain extent, led the way, compared with other receptor systems, in the appreciation that ligands may exert very diverse pharmacology, based on their individual chemical structure and the allosteric changes induced in the receptor/accessory protein complex. This can lead to very selective pharmacological effects, which may not necessarily be predicted f...
results among a total of 152 subjects, 82.9% were female and their mean age was 22.57 ± 1.55 years. according to the students, instructors had the weakest performance in the three items of teaching pharmacology and medication management based on the students’ learning needs, teaching medication management through a patient-centered method and teaching pharmacology and medication management base...
GABA(A) receptor channels are ubiquitous in the mammalian central nervous system mediating fast inhibitory neurotransmission by becoming permeant to chloride ions in response to GABA. The emphasis of this review is on the rich chemical diversity of ligands that influence GABA(A) receptor function. Such diversity provides many avenues for the design and development of new chemical entities actin...
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