In vitro selection with long random RNA libraries has been used as a powerful method to generate novel functional RNAs, although it often requires laborious structural analysis of isolated RNA molecules. Rational RNA design is an attractive alternative to avoid this laborious step, but rational design of catalytic modules is still a challenging task. A hybrid strategy of in vitro selection and ...

M. Oaksford and N. Chater (O&C; 1994) presented the first quantitative model of P. C. Wason's ( 1966, 1968) selection task in .which performance is rational. J. St B T Evans and D. E. Over (1996) reply that O&C's account is normatively incorrect and cannot model K. N. Kirby's (1994b) or P. Pollard and J. St B T Evans's (1983) data. It is argued that an equivalent measure satisfies their normati...

This contribution deals with the problem of structure determination for generalized orthonormal basis models used in system identiication. The model structure is parameterized by a pre-speciied set of poles. Given this structure and experimental data a model can be estimated using linear regression techniques. Since the variance of the estimated model increases with the number of estimated para...

Mobile agents have the ability to migrate through heterogeneous networks and execute at remote hosts. This ability can be exploited to improve the performance of agent based applications by transferring agents to less heavily loaded hosts or by adapting the client/server interactions to the network load. That is, rather than transferring raw data through a bottleneck link, a small sized agent m...

In agent theory and agent programming, goals constitute the motivational attitude of rational agents and form the key concept in explaining and generating their pro-active behavior. Pursuing multiple goals simultaneously might pose problems for agents as the plans for achieving them may conflict. We argue that a BDI-based agent programming language should provide constructs to allow an agent pr...

I analyze a market with asymmetric information, interdependent values, multiple trading opportunities and trade frictions. The frictions can be reduced at a cost, e.g. by increasing attention, search or computing power. Raising the difference between the values of buyers and sellers can delay trade, despite the greater gains from trade. Rejecting an initial offer is a stronger signal when the o...

In this article, the problems encountered in the rational use of drugs are discussed, one of the areas of optimization of drug supply being the rational choice of drugs, particularly, a regulatory activity regarding the approach to the selection of standardized drug lists (drug formulary) for public drug supply, according to government guarantees and programs. !e clinical aspects of the drug se...