A validated HPLC method was developed to determine doxorubicin concentration in a small volume of rat plasma (60 µl) with convenient fluorescence detection. Sample preparation includes a simple one-step liquid-liquid extraction using minimum amount of organic solvent, with extraction recoveries more than 95%. The analysis was accomplished using PerfectSil C18 column maintained at 35 °C and a mo...

A validated HPLC method was developed to determine doxorubicin concentration in a small volume of rat plasma (60 µl) with convenient fluorescence detection. Sample preparation includes a simple one-step liquid-liquid extraction using minimum amount of organic solvent, with extraction recoveries more than 95%. The analysis was accomplished using PerfectSil C18 column maintained at 35 °C and a mo...

chinese jujube (ziziphus jujuba mill.) has long been widely used for human consumption and medicinal purposes in china. it has been reported to possess several vital biological activities. however, the systematic study on the chemical constituents absorbed into plasma and their metabolites is still insufficient. a high-performance liquid chromatography-photodiode array detector-electrospray ion...

Abstract Objective This study aimed to evaluate the effect of swimming training (T) on renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks. Results The SUD impaired physical performance, increased adiposity index (BAI), Lee (LI) retroperitoneal adipose tissue (RAT) weight, plasma creatinine number cells nuclei, decreased urinary v...

Current palliative pharmacotherapy of Alzheimer’s disease based on the cholinergic hypothesisled to the development of four cholinesterase inhibitors. These compounds can bring prolongationof the symptom-free period in some patients. This is the frst report directly comparing donepeziland rivastigmine plasma and brain levels in <span class="font...

Current palliative pharmacotherapy of Alzheimer’s disease based on the cholinergic hypothesisled to the development of four cholinesterase inhibitors. These compounds can bring prolongationof the symptom-free period in some patients. This is the frst report directly comparing donepeziland rivastigmine plasma and brain levels in <span class="font...

1. The musculotropic activity of eledosin on the isolated guinea-pig ileum is antagonized by morin, a flavonoid derivative.2. The anti-eledoisin activity of morin is abolished by fresh rat plasma and by deproteinized rat plasma, but not by deionized plasma.3. Cupric acetate can restore the inhibitory property of the deionized plasma and can also inactivate morin.4. This effect of rat plasma and...

1. Rat sarcoma may be cultivated in mouse plasma and guinea pig plasma, and the growth differs only in extent from that observed in rat plasma. The cells may show active wandering in guinea pig plasma after thirty days, if transferred at proper intervals to fresh medium. 2. Rabbit plasma is less suitable than that of guinea pigs and mice for the growth of rat sarcoma; growth is slow, but it may...