نتایج جستجو برای: rat estrogen

تعداد نتایج: 315014  

Journal: :American journal of physiology. Heart and circulatory physiology 2005
Min Li John N Stallone

To determine the roles of estrogen and constrictor prostanoids in vasopressin (VP)-induced contraction of female rat aorta, vascular reactivity to VP was determined in thoracic aortas of intact, ovariectomized, and ovariectomized + estrogen-replaced female rats in the presence of indomethacin (Indo), NS-398, SQ-29,548, or vehicle control. The effects of estrogen on vascular reactivity to the th...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
Derek T Solum Robert J Handa

During development, estrogen has a variety of effects on morphological and electrophysiological properties of hippocampal neurons. Brain-derived neurotrophic factor (BDNF) also plays an important role in the survival and differentiation of neurons during development. We examined the effects of gonadectomy with and without estrogen replacement on the mRNA and protein of BDNF and its receptor, tr...

Journal: :The Journal of endocrinology 2006
Ichiro Sakata Toru Tanaka Mami Yamazaki Takashi Tanizaki Zhao Zheng Takafumi Sakai

Ghrelin, an endogenous ligand for the GH secretagogue receptor, is predominantly produced in the stomach. Little is known about the regulation mechanism of gastric ghrelin. Here, we report that estrogen synthesized in the stomach induces rat gastric ghrelin gene expression and production. We established a gastric ghrelin cell enrichment method using Percoll centrifugation and then studied the e...

Journal: :Cancer research 1981
L L Tilzer R T McFarland F V Plapp J P Evans M Chiga

Estrogen receptors from rat uterus and human breast carcinoma were analyzed by diethylaminoethyl-cellulose chromatography. Cytosols which had been incubated for short periods of time demonstrated a single discrete elution peak, indicating a single ionic form, while cytosols incubated for longer periods of time generated a second ionic form of receptor. Addition of cations to cytosols also promo...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1975
E A Ham V J Cirillo M E Zanetti F A Kuehl

Endogenous uterine prostaglandin levels were monitored in the cycling rat and prostaglandins of the F-type were found to rise at proestrus when estrogen levels have been shown to be maximal. Evidence that this is an estrogen-induced event is furnished by the finding that estradiol-17beta caused a similar rise in prostaglandin F levels in uteri of ovariectomized rats, an action blocked by coadmi...

2009
Takashi Miyakoshi Hanako Kajiya Katsuhiro Miyajima Mao Takei Maya Tobita Susumu Takekoshi Robert Yoshiyuki Osamura

Wnt signaling is important in many aspects of cell biology and development. In the mouse female reproductive tract, Wnt4, Wnt5a, and Wnt7a show differential expression during the estrus cycle, suggesting that they participate in female reproductive physiology. Although the pituitary is a major gland regulating reproduction, the molecular mechanism of Wnt signaling here is unclear. We elucidated...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1994
F Sohrabji R C Miranda C D Toran-Allerand

We have previously shown that neurons in the basal forebrain colocalize the neurotrophin receptor p75NGFR and estrogen receptors. The present study was designed to examine (1) if neural neurotrophin targets respond to estrogen as a general phenotypic feature and (2) if NGF receptor mRNAs are regulated by estrogen, using a prototypical target of NGF, the dorsal root ganglion (DRG) (sensory) neur...

Journal: :Fertility and sterility 2009
Bahadir Saatli Sefa Kizildag Cemal Posaci Erbil Dogan Meral Koyuncuoglu E Cagnur Ulukus Nese Atabey

OBJECTIVE To define the long-term effects of GnRH antagonist, GnRH agonist, and estrogen plus progesterone treatments on apoptosis and apoptosis-related gene expressions, including bcl2, bax, and cyt c in rat ovary. DESIGN Prospective placebo-controlled experimental study. SETTING Obstetrics and Gynecology and Medical Biology and Genetics university departments. ANIMAL(S) Forty female wis...

Journal: :The Journal of biological chemistry 1981
J L Borgna H Rochefort

After in vivo administration of [3H]tamoxifen to immature female rats and chickens, polar metabolites of tamoxifen were found in plasma, liver, uterus, and oviduct. 4-Hydroxytamoxifen and M2, another hydroxylated metabolite of tamoxifen, were the major tritiated compounds of the cytosol and the KCl-nuclear extract of target tissues and appeared to occupy the estrogen receptor sites since their ...

Journal: :Bioinformation 2023

Estradiol, a major form of estrogen, plays crucial role in various aspects brain function, including neuronal health, synaptic plasticity, and cognitive processes. Therefore, it is interest to investigate the histopathological changes rat following estradiol treatment unilateral bilateral ovariectomized rats, commonly used method induce estrogen deficiency study consequences hormonal changes. T...

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