نتایج جستجو برای: rassf1a

تعداد نتایج: 855  

Journal: :Circulation 2009
Delvac Oceandy Adam Pickard Sukhpal Prehar Min Zi Tamer M A Mohamed Peter J Stanley Florence Baudoin-Stanley Raja Nadif Stella Tommasi Gerd P Pfeifer Angel L Armesilla Elizabeth J Cartwright Ludwig Neyses

BACKGROUND Ras signaling regulates a number of important processes in the heart, including cell growth and hypertrophy. Although it is known that defective Ras signaling is associated with Noonan, Costello, and other syndromes that are characterized by tumor formation and cardiac hypertrophy, little is known about factors that may control it. Here we investigate the role of Ras effector Ras-ass...

2004
Sarah L. Fenton Ashraf Dallol Angelo Agathanggelou Luke Hesson Jalal Ahmed-Choudhury Shairaz Baksh Claude Sardet Reinhard Dammann John D. Minna Julian Downward Eamonn R. Maher Farida Latif

Epigenetic inactivation of the candidate tumor suppressor gene RASSF1A is a frequent and critical event in the pathogenesis of many human cancers. The RASSF1A protein contains a Ras association domain, suggesting a role in Ras-like signaling pathways, and has also been implicated in cell cycle progression. However, the preliminary data suggests that the RASSF1A gene product is likely to have mu...

2009
Sonja Thaler Patricia S. Hähnel Arno Schad Reinhard Dammann Martin Schuler

Promoter hypermethylation preventing expression of the RAS association domain family 1 isoform A (RASSF1A) gene product is among the most abundant epigenetic deregulations in human cancer. Restoration of RASSF1A inhibits tumor cell growth in vitro and in murine xenograft models. Rassf1adeficient mice feature increased spontaneous and carcinogeninduced tumor formation. Mechanistically, RASSF1A a...

Journal: :Molecular cancer research : MCR 2014
Lingyan Jiang Rong Rong M Saeed Sheikh Ying Huang

UNLABELLED The tumor suppressor RAS-association domain family 1 isoform A (RASSF1A) is known to play an important role in cell-cycle regulation. However, the molecular details about RASSF1A protein regulation are unclear. In this report, checkpoint kinase 1 (CHK1) is identified as a novel RASSF1A kinase that phosphorylates RASSF1A in vitro and under cellular conditions. Using tandem mass spectr...

Journal: :Genetics and molecular research : GMR 2016
Y Q Huang H Guan C H Liu D C Liu B Xu L Jiang Z X Lin M Chen

Epigenetic inactivation of Ras-associated domain family 1A (RASSF1A) by hyper-methylation of its promoter region has been identified in various cancers. However, the role of RASSF1A in renal cancer has neither been thoroughly investigated nor reviewed. In this study, we reviewed and performed a meta-analysis of 13 published studies reporting correlations between methylation frequency of the RAS...

Journal: :Cancer research 2005
Jalal Ahmed-Choudhury Angelo Agathanggelou Sarah L Fenton Christopher Ricketts Geoffrey J Clark Eamonn R Maher Farida Latif

Recent advances in the study of RASSF1A, the candidate tumor suppressor gene, indicate a possible role of RASSF1A in cell cycle regulation; however, very little is known regarding molecular mechanisms underlying this control. Using small interfering RNA to knockdown endogenous RASSF1A in the breast tumor cell line HB2 and in the cervical cancer cell line HeLa, we identify that a key player in c...

2013
Dan Cao Ye Chen Yuan Tang Xing-Chen Peng Hang Dong Long-Hao Li Ke Cheng Jun Ge Ji-Yan Liu

BACKGROUND The RAS-association domain family 1 A (RASSF1A) is a classical member of RAS effectors regulating cell proliferation and apoptosis. Loss of RASSF1A expression may shift the balance towards a growth-promoting effect without the necessity of activating K-ras mutations. Its potential association with K-ras mutations in colorectal cancer (CRC) is unclear. METHODS RASSF1A expression was...

Journal: :Cancer research 2009
Su Jung Song Soon Jung Kim Min Sup Song Dae-Sik Lim

Aurora B is critically involved in ensuring proper cytokinesis and maintaining genomic stability. The tumor suppressor RASSF1A regulates cell cycle progression by regulating mitotic progression, G(1)-S transition, and microtubule stability. We previously reported that both Aurora A and Aurora B phosphorylate RASSF1A, and showed that phosphorylation of RASSF1A by Aurora A blocks the inhibitory f...

Journal: :Cancer research 2006
Hyun Jung Oh Kyung-Kwon Lee Su Jung Song Mi Sun Jin Min Sup Song Joo Hyun Lee Chang Rak Im Jie-Oh Lee Shin Yonehara Dae-Sik Lim

Mammalian sterile 20-like kinase 1 (Mst1) is activated by both caspase-mediated cleavage and phosphorylation in response to apoptotic stimuli, including Fas ligation. Here, we examined the possible role of the tumor suppressor RASSF1A in Mst1 activation and Mst1-mediated apoptosis induced by death receptor signaling. Immunoprecipitation and immunofluorescence analyses revealed that Mst1 was ass...

Journal: :Cancer research 2005
Young Mi Whang Yeul Hong Kim Jun Suk Kim Young Do Yoo

Some oncogenes, such as activated Ras, cause the malignant transformation of lung cells. c-Jun-NH2-kinase (JNK) activation is essential for the oncogenic function of these cells. In this study, we show that RASSF1A inhibits the growth of lung cancer cells by blocking the JNK pathway. The exogenous expression of RASSF1A suppressed JNK phosphorylation, and cells stably transfected with RASSF1A sh...

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