نتایج جستجو برای: ras superfamily
تعداد نتایج: 45433 فیلتر نتایج به سال:
Over the past several years, a large superfamily of monomeric GTP-binding proteins structurally related to the ras oncogene proteins has been described (1-4). The number of members of this superfamily identified has increased dramatically in recent years, and the number of descriptive terms or names used to denote these proteins has increased almost as dramatically as well. During the recent FA...
Using microarray analysis, we identified a unique ras superfamily gene, termed RERG (ras-related and estrogen-regulated growth inhibitor), whose expression was decreased or lost in a significant percentage of primary human breast tumors that show a poor clinical prognosis. Importantly, high RERG expression correlated with expression of a set of genes that define a breast tumor subtype that is e...
In every organism, GTP-binding proteins control many aspects of cell signaling. Here, we examine in silico several GTPase families from the Strongylocentrotus purpuratus genome: the monomeric Ras superfamily, the heterotrimeric G proteins, the dynamin superfamily, the SRP/SR family, and the "protein biosynthesis" translational GTPases. Identified were 174 GTPases, of which over 90% are expresse...
The Ras superfamily of small GTPases are single domain nucleotide-dependent molecular switches that act as highly tuned regulators of complex signal transduction pathways. Originally identified in eukaryotes for their roles in fundamental cellular processes including proliferation, motility, polarity, nuclear transport, and vesicle transport, recent studies have revealed that single domain GTPa...
Rab 25 is a small GTPase belonging to the RAS (rat sarcoma) superfamily. It expressed in epithelial cells only and serves as regulator of various intracellular signaling pathways. As key player cell regulation, has been shown by research function mainly an oncogene cancers including breast cancer ovarian cancer. However, also reported be tumor suppressor types such colorectal A lot done about r...
Ras superfamily GTPases act as molecular switches that generally cycle between a GDP-bound “off” state and GTP-bound “on” state. The conformational changes associated with these different states are involved in the regulation of multiple cellular processes. Despite significant efforts to directly target activity, no anti-Ras drugs have been developed taken into clinic. Being nightmare for drug ...
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