Marginalization is one of the consequences of economic and social crises in Iran during recent years, which has caused many problems on the margin of large cities such as Tehran. Lack of living standards, as well as urban management supervision, have caused environmental problems to be one of the damages of these areas to its inhabitants and surrounding urban areas. Environmental degradations i...

Regulation of integrins is critical for lymphocyte adhesion to endothelium and trafficking through secondary lymphoid organs. Inside-out signaling to integrins is mediated by the small GTPase Rap1. Two effectors of Rap1 regulate integrins, RapL and Rap1 interacting adaptor molecule (RIAM). Using mice conditionally deficient in both Rap1a and Rap1b and mice null for RIAM, we show that the Rap1/R...

There is a strong mutuality between tourism and environment via the creation of feedback mechanisms, since tourism often places adverse effects upon the quality and quantity of natural and cultural resources of the destination, leading to its qualitative and quantitative degradation. Within theEnvironmental Impacts Assessment (EIA) studies, various methods have been proposed to assess and analy...

Cell migration and invasion require regulated turnover of integrin-dependent adhesion complexes. Rap1-GTP-interacting adaptor molecule (RIAM) is an adaptor protein that mediates talin recruitment to the cell membrane, and whose depletion leads to defective melanoma cell migration and invasion. In this study, we investigated the potential involvement of RIAM in focal adhesion (FA) dynamics. RIAM...

The small GTPase Rap1 induces integrin-mediated adhesion and changes in the actin cytoskeleton. The mechanisms that mediate these effects of Rap1 are poorly understood. We have identified RIAM as a Rap1-GTP-interacting adaptor molecule. RIAM defines a family of adaptor molecules that contain a RA-like (Ras association) domain, a PH (pleckstrin homology) domain, and various proline-rich motifs. ...

there is a strong mutuality between tourism and environment via the creation of feedback mechanisms, since tourism often places adverse effects upon the quality and quantity of natural and cultural resources of the destination, leading to its qualitative and quantitative degradation. within theenvironmental impacts assessment (eia) studies, various methods have been proposed to assess and analy...

bus rapid transit is an innovative, high capacity, lower cost public transit solution in metropolitan cities. idea is to dedicate lanes for quick and efficient transport of passengers to their destinations. in the present investigation the environmental impact assessment of bus rapid transit  in tehran metropolitan city is brought out. for this purpose bus rapid transit lane no. 10 is investiga...