There is a general agreement that before a therapy can be accepted into widespread clinical use, demonstration of efficacy in randomized clinical trials (RCTs) is absolutely necessary. There are, however, a growing number of experts who believe that demonstration of RCT efficacy might not be a sufficient basis for widespread acceptance.1 RCTs may not enroll subjects representative of patients i...

There is a general agreement that before a therapy can be accepted into widespread clinical use, demonstration of efficacy in randomized clinical trials (RCTs) is absolutely necessary. There are, however, a growing number of experts who believe that demonstration of RCT efficacy might not be a sufficient basis for widespread acceptance.1 RCTs may not enroll subjects representative of patients i...

BACKGROUND Randomized clinical trials (RCTs) are an important source of evidence for clinical practice, but finding and applying RCT reports to care is time consuming. Publishing RCTs directly into machine-understandable "trial banks" may allow computers to deliver RCT evidence more selectively and effectively to clinicians. METHODS Authors of eligible RCTs published in JAMA or the Annals of ...

The randomized clinical trial (RCT) is a powerful experimental design that when properly executed produces generalizable results. Conducting a RCT becomes complex when technical skills are required. Without requisite skills, a RCT may yield misleading results, an elegant RCT unwittingly generating spurious results due to technical inexperience. This pitfall is applicable to procedures used to e...

Background: In attention of increasing prevalence psychological problems, complications and consequences of hemodialies and important role of nurses in psychological support of patients, application of complementary therapies such as spirituality counseling is very important. Aim: This study investigates the effect of spirituality counseling on anxiety and depression in hemodialysis patient. Me...

The randomized controlled trial (RCT) methodology is often considered to reveal the most accurate data on a product’s safety and effectiveness. However, the value of an RCT post-approval is limited as clinical trial cohorts rarely represent the general patient population in real-life settings. Observational studies on the other hand yield better evaluations for safety and effectiveness in routi...