Outcome-adaptive randomization allocates more patients to the better treatments as the information accumulates in the trial. Is it worth it to apply outcome-adaptive randomization in clinical trials? Different views permeate the medical and statistical communities. We provide additional insights to the question by conducting extensive simulation studies. Trials are designed to maintain the type...

Randomization as a method of experimental control has been extensively used in clinical trials. Generating the randomization schedule has been an essential part of some trials. We discuss how to use SAS programming and SAS PROC PLAN to generate the randomization schedule. The issues related to randomization are also discussed. Case studies are used to illustrate the use of SAS programming and S...