Advances in instrumentation are making Raman spectroscopy the tool of choice for an increasing number of (bio)chemical applications. Raman is an interesting option for several reasons, including the sensitivity to small structural changes, non-invasive sampling capability, minimal sample preparation, and high spatial resolution in the case of Raman micro-spectroscopy. Herein we discuss the most...

Adoption of Quality by Design (QbD) principles, regulatory support of QbD, process analytical technology (PAT), and continuous manufacturing are major factors effecting new approaches to pharmaceutical manufacturing and bioprocessing. In this review, we highlight new technology developments, data analysis models, and applications of Raman spectroscopy, which have expanded the scope of Raman spe...

Laser micro-Raman spectroscopy is an ideal tool for assessment and characterization of various types of carbon-based materials. Due to its special optical properties (CrN) coated stainless steel substrates. NCD films have been investigated by laser micro-Raman spectroscopy. The fingerprint of diamond based materials is in the spectral region of 1000-1600 cm-1 in the first order of Raman scatter...

Gallium nitride (GaN) nanostructures (NS) were synthesized using pulseddirect current plasma enhanced chemical vapor deposition (PDC-PECVD) on quartzsubstrate at low temperature (600°C). Gallium metal (Ga) and nitrogen (N) plasma wereused as precursors. The morphology and structure of the grown GaN NS werecharacterized by field emission scanning electron microscope (FE-SEM), transmissionelectro...

Resulting from the combination of Raman spectroscopy and optical microscopy, Raman hyperspectral imaging has proven to be an indispensable tool in the pharmaceutical field. This article will broach a number of Raman hyperspectral imaging applications that were developed in our laboratory, in order to demonstrate the significance of the technique. Raman Spectroscopy Raman Hyperspectral Imaging: ...

A novel tip-enhanced Raman spectroscopy setup with longitudinal field excitation generated by a plasmonic lens is investigated. A symmetry-breaking structure plasmonic lens that is expected to realize a strong longitudinal electric field focus has been designed to generate suitable excitation for enhancement in a tip antenna. The focusing performance of the plasmonic lens is theoretically simul...

While cellulosic and lignocellulosic materials have been studied using conventional Raman spectroscopy, availability of near-infrared (NIR) Fourier transform (FT) Raman instrumentation has made studying these materials much more convenient.1 This is especially true because the problem of laser-induced fluorescence can be avoided or minimized in FT-Raman (NIR Raman) spectroscopy. More recently, ...

Silicon oxynitride-based arrayed waveguide grating (AWG) spectrometers were designed for on-chip spectral-domain optical coherence tomography (OCT) systems and Raman spectroscopy of the skin. A novel geometrical layout for Raman spectroscopy was introduced to reduce loss. Measurements show that integrated optics has a good potential for miniaturizing current OCT systems. Keywords-arrayed wavegu...

As a fast, label-free and non-invasive detection method, Raman spectroscopy has been widely used for the interrogation of biological tissues, any alterations of molecular structure and chemical components during pathological processes would be identified and revealed via the differences on Raman spectrum. In clinics, the Raman spectroscopy has great potentials to provide real-time scanning of l...