n engl j med 367;8 nejm.org august 23, 2012 746 This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presente...

Divergence paralysis is characterized by acquired horizontal homonymous diplopia when viewing distant objects but without limitation of ocular movements (Bielschowsky, I935). Although raised intracranial pressure is a significant aetiological factor in the production of divergence paralysis (Bender and Savitsky, I940; Chamlin and Davidoff, I950, 1951), there has been much diversity of opinion a...

In eight anaesthetized, ventilated adult baboons, the intracranial volume-pressure response was examined at differing levels of raised intracranial pressure during induced changes in systemic arterial pressure and cerebral blood flow. The volume-pressure response is defined as the change in ventricular fluid pressure caused by a volume addition of 0·05 ml to the lateral ventricle. At normal int...

This article is the second of two examining the causes of increased intracranial pressure in children. Key features and management associated with brain tumours and intracranial bleeds are highlighted. The conditions are accompanied by illustrative case studies to give an idea of what children's nurses may encounter in a patient presenting with raised intracranial pressure. Part one, published ...