نتایج جستجو برای: radiosynthesis
تعداد نتایج: 363 فیلتر نتایج به سال:
Reactive oxygen species (ROS) play important roles in cell signaling and homeostasis. However, an abnormally high level of ROS is toxic, and is implicated in a number of diseases. Positron emission tomography (PET) imaging of ROS can assist in the detection of these diseases. For the purpose of clinical translation of [18F]6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methyl-...
Radiolabeled tracers targeting the prostate-specific membrane antigen (PSMA) have become important radiopharmaceuticals for the PET-imaging of prostate cancer. In this connection, we recently developed the fluorine-18-labelled PSMA-ligand [18F]PSMA-1007 as the next generation radiofluorinated Glu-ureido PSMA inhibitor after [18F]DCFPyL and [18F]DCFBC. Since radiosynthesis so far has been suffer...
In this study, radiosynthesis and biological evaluation of a new [18F]labeled glutamine analogue, N-(2-[18F]fluoropropionyl)-L-glutamine ([18F]FPGLN) for tumor PET imaging are performed. [18F]FPGLN was synthesized via a two-step reaction sequence from 4-nitrophenyl-2-[18F]fluoropropionate ([18F]NFP) with a decay-corrected yield of 30 ± 5% (n=10) and a specific activity of 48 ± 10 GBq/μmol after...
New radiochemistry techniques can yield novel PET tracers for COX-2 and address the shortcomings in in vivo stability and specificity, which have held back clinical translation of tracers to image COX-2 expression. Current techniques limit radiosynthesis to analogs of the COX-2 inhibitors with fluorine-18 added via a carbon chain, or on an aromatic position which renders the radiolabeled analog...
Background A family of tropomyosin receptor kinases (TrkA/B/C) plays important roles in the regulation neuronal differentiation, growth, and survival via their interactions with neurotrophins. growing body literature suggests downregulation Trk many neurodegenerative conditions central nervous system (CNS), including Alzheimer’s disease (AD). We recently reported development [18F]TRACK, PET tra...
Nordeman, P. 2014. Development of Palladium-Promoted C/C-Carbonylations and Radiosynthesis of Amyloid PET Ligands. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 183. 76 pp. Uppsala: Uppsala universitet. ISBN 978-91-554-8843-7. In the first part of this thesis, palladium(0)-catalyzed and -mediated carbonylations are discussed. Paper I describes a new metho...
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