Overexpression of human epidermal growth factor receptor 2 (HER2) is found in about 20% of breast cancer patients. With treatment using trastuzumab, an anti-HER2 monoclonal antibody, systemic control is improved. Nonetheless, the incidence of brain metastasis does not be improved, rather seems to be increased in HER2-positive breast cancer. The mainstay treatment for brain metastases is radioth...

Ovarian cancer has the highest mortality rate among gynecological cancers; the most effective therapy for this cancer is a combination of radiation treatment and chemotherapy. However, radiation resistance is the leading factor associated with treatment failure. The present study aimed to investigate pseudolaric acid B (PAB) as a potential radiosensitizer for the treatment of ovarian cancer. Th...

Hypertermia (HT) is a radiosensitizer and also a cytotoxic treatment modality. HT inhibits lethal damage and sublethal damage repair. Different devices are used but no gold standart equipment is advised by authorities. HT kills tumor cells itself or sensitize them for the treatment outcomes for chemotherapy and radiotherapy. Thermotolerance is a special condition that immune response occurs aga...

Radioresistance is the predominant cause for radiotherapy failure and disease progression, resulting in increased breast cancer‑associated mortality. Using gene expression signature analysis of Library Integrated Network‑Based Cellular Signatures (LINCS) Gene Expression Omnibus (GEO), aim present study was to systematically identify potential candidate radiosensitizers from known drugs. The sim...

PURPOSE Hypoxia is an important characteristic of the solid tumor microenvironment and constitutes a barrier for effective radiotherapy. Here, we studied the effects of darinaparsin (an arsenic cytotoxin) on survival and radiosensitivity of tumor cells in vitro under normoxia and hypoxia and in vivo using xenograft models, compared to effects on normal tissues. EXPERIMENTAL DESIGN The cytotox...

PURPOSE In view of the documented toxicity of continuous daily radiosensitizer doses of temozolomide concomitant with radiation in the treatment of glioblastoma multiforme, we aimed to compare it with a different schedule of abbreviated radiosensitizer dosing. PATIENTS AND METHODS This was a randomized prospective study comparing toxicity and survival in 60 Egyptian patients with glioblastoma...