نتایج جستجو برای: radiosensitivity

تعداد نتایج: 3339  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Christopher A Barker William E Burgan Donna J Carter David Cerna David Gius Melinda G Hollingshead Kevin Camphausen Philip J Tofilon

PURPOSE Because ribonucleotide reductase (RR) plays a role in DNA repair, it may serve as a molecular target for radiosensitization. Unlike previously investigated RR inhibitors, Triapine potently inhibits both RR holoenzymes. Therefore, the effects of Triapine on tumor cell radiosensitivity were investigated. EXPERIMENTAL DESIGN The effects of Triapine on the in vitro radiosensitivity of thr...

Journal: :Cancer research 2006
Leo E Gerweck Shashirekha Vijayappa Akihiro Kurimasa Kazuhiko Ogawa David J Chen

Substantial evidence suggests that the radiosensitivity of the tumor cells is the primary determinant of tumor response to radiation. More recent studies suggest that tumor stroma radiosensitivity is the principle determinant of response. To assess the relationship between intrinsic tumor cell radiosensitivity and tumor response, we altered the intrinsic radiosensitivity of a cloned tumor cell ...

2017
Mohammad Habash Luis C. Bohorquez Elizabeth Kyriakou Tomas Kron Olga A. Martin Benjamin J. Blyth

Whilst the near instantaneous physical interaction of radiation energy with living cells leaves little opportunity for inter-individual variation in the initial yield of DNA damage, all the downstream processes in how damage is recognized, repaired or resolved and therefore the ultimate fate of cells can vary across the population. In the clinic, this variability is observed most readily as rar...

Journal: :Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology 2011
Elitsa Encheva Sofia Deleva Rositsa Hristova Valeria Hadjidekova Tatiana Hadjieva

BACKGROUND Pelvic organs morbidity after irradiation of cancer patients remains a major problem although new technologies have been developed and implemented. A relatively simple and suitable method for routine clinical practice is needed for preliminary assessment of normal tissue intrinsic radiosensitivity. The micronucleus test (MNT) determines the frequency of the radiation induced micronuc...

2017
Annelot Baert Julie Depuydt Tom Van Maerken Bruce Poppe Fransiska Malfait Tim Van Damme Sylvia De Nobele Gianpaolo Perletti Kim De Leeneer Kathleen B.M. Claes Anne Vral

Breast cancer risk drastically increases in individuals with a heterozygous germline BRCA1 or BRCA2 mutation, while it is estimated to equal the population risk for relatives without the familial mutation (non-carriers). The aim of the present study was to use a G2 phase-specific micronucleus assay to investigate whether lymphocytes of healthy BRCA2 mutation carriers are characterized by increa...

2012
Seog-Young Kim Juong G. Rhee Xinxin Song Edward V. Prochownik Douglas R. Spitz Yong J. Lee

There are contradictory observations about the different radiosensitivities of cancer stem cells and cancer non-stem cells. To resolve these contradictory observations, we studied radiosensitivities by employing breast cancer stem cell (CSC)-like MDA-MB231 and MDA-MB453 cells as well as their corresponding non-stem cells. CSC-like cells proliferate without differentiating and have characteristi...

2012
Luqing Zhao Ann M. Bode Ya Cao Zigang Dong

MicroRNA (miRNA) influences carcinogenesis at multiple stages and it can effectively control tumor radiosensitivity by affecting DNA damage repair, cell cycle checkpoint, apoptosis, radio-related signal transduction pathways and tumor microenvironment. MiRNA also efficiently modulates tumor radiosensitivity at multiple levels by blocking the two essential non-homologous end-joining repair and h...

Journal: :Cancer research 2012
Thomas J Hayman Eli S Williams Muhammad Jamal Uma T Shankavaram Kevin Camphausen Philip J Tofilon

A core component in the cellular response to radiation occurs at the level of translational control of gene expression. Because a critical element in translation control is the availability of the initiation factor eIF4E, which selectively enhances the cap-dependent translation of mRNAs, we investigated a regulatory role for eIF4E in cellular radiosensitivity. eIF4E silencing enhanced the radio...

2012
RADHA SARASWATHY K. M. MARIMUTHU

It is a well established radiobiological concept that no radiation doses can be considered completely safe. Radiobiologists have been struggling to estimate the health risks from low doses of radiation in human beings for decades. Little is known on the underlying predisposition of the individuals so affected. Hence in this study few established precancerous chromosomal syndromes were subjected...

2014
Judith Auer Ulrike Keller Manfred Schmidt Oliver Ott Rainer Fietkau Luitpold V. Distel

BACKGROUND Individual radiosensitivity has a crucial impact on radiotherapy related side effects. Our aim was to study a breast cancer collective for its variation of individual radiosensitivity depending on the patients' age. MATERIALS AND METHODS Peripheral blood samples were obtained from 129 individuals. Individual radiosensitivity in 67 breast cancer patients and 62 healthy individuals w...

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