Lipopolysaccharide-initiated rejection of a tumor allograft requires the cooperation of a radiosensitive nonadherent lymphoid cell population and an adherent cell, presumably a macrophage.

computed tomographyrepresents about 10% of all diagnostic radiology procedures, but it isresponsible for almost 50% - 60% of exposure from diagnostic procedures. inhead ct, other critical organs such as eye lenses and thyroids are in theradiation field. therefore, dose assessment in these organs is very important.the aim of this study is to estimate the absorbed dose in critical organs ofpatien...

BACKGROUND Glioblastoma multiforme (GBM) is a high-grade primary brain tumor that is refractory to current forms of treatment. In cell studies, the growth rate of GBM cells correlates with the level of Cyclooxygenase-2 (COX-2) enzyme expression. COX-2 has been implicated in carcinogenesis of systemic cancers. Recently, COX-2 inhibition has been shown to increase the radiosensitivity of various ...

Solitary extramedullary plasmacytomas (SEP) of larynx are rare tumors and are radiosensitive. However, a case of radioresistant SEP of larynx was managed by endoscopic CO2 excision.

It is important to know whether the human population includes genetically predisposed radiosensitive subsets. In vitro studies have shown that cells from individuals homozygous for ataxia telangiectasia (A-T) are much more radiosensitive than cells from unaffected individuals. Although cells heterozygous for the ATM gene (ATM(+/-)) may be slightly more radiosensitive in vitro, it remained to be...

Canine cancer cell lines have progressively been developed, but are still underused resources for radiation biology research. Measurement of the cellular intrinsic radiosensitivity is important because understanding the difference may provide a framework for further elucidating profiles for prediction of radiation therapy response. Our studies have focused on characterizing diverse canine cance...

The radiation sensitivity of cells isolated directly from surgical specimens of the primary tumor and one to three distant metastases in ten different melanoma patients was measured in vitro using the Courtenay soft agar colony assay. Dose-response curves were fitted to the cell survival data by the method of least squares using the multitarget-single hit and the linear-quadratic models. The te...

PURPOSE Non-small cell lung cancer (NSCLC) includes a spectrum of radiosensitive and radioresistant tumors. However, little is known about the molecular determinants of cellular radiation responses. We examined clinical outcomes after gamma knife radiotherapy for NSCLC intracranial metastases to evaluate the use of this model for determining radiosensitive tumor genotypes. EXPERIMENTAL DESIGN...

The TLR5 agonist flagellin induces innate and adaptive immune responses in a MyD88-dependent manner and is under development as a vaccine adjuvant. In vitro studies indicate that, compared with other bacteria-derived adjuvants, flagellin is a very potent activator of proinflammatory gene expression and cytokine production from cells of nonhemopoietic origin. However, the role of nonhemopoietic ...