a “cocktail”of several probe drugs is often used to evaluate metabolic activity of multiple cytochrome p450 enzymes in one session. some interactions among probe drugs can appear and may impact the rate of biotransformation of other ones. our presented work was to aim on the influence of bupropion on rat cytochrome p450-mediated metabolism of tolbutamide. the biotransformation rates of tolbutam...

Scintigraphy of the parathyroid glands continues to be controversial from several standpoints, including radiopharmaceutical choice, imaging protocol, results, and utility in clinical situations. This article reviews: the anatomy, physiology and pathology of the parathyroid glands; mechanisms of radiopharmaceutical localization; commonly accepted imaging protocols; image results; and the approp...

INTRODUCTION Preoperative wire-guided localisation (WGL) of impalpable breast lesions is widely used but can be technically difficult. Risks include wire migration, inaccurate placement, and inadequate surgical margins. Research shows that radioguided occult lesion localisation (ROLL) is quicker, easier, and can improve surgical and cosmetic outcomes. An audited introduction of ROLL was conduct...

T he 11th International Conference of Radiopharmaceutical and Molecular Therapy (ICRT) was held in Kochi, Kerala, India, November 13–17, and was organized under the umbrella of the World Association of Radiopharmaceutical and Molecular Therapy (WARMTH) and in cooperation with the International Atomic Energy Agency. The meeting included presentations on various applications of radionuclides for ...

The LNE-LNHB, in charge of the French standards for radionuclide metrology, develops primary measurement methods intended for the calibration of secondary measuring instruments, such as used in hospitals, to determine the activity of radiopharmaceuticals injected into patients. The triple-to-double coincidence ratio (TDCR) method, based on liquid scintillation counting, is widely implemented fo...

The renaissance of Ga radiopharmacy has led to great advances in automation technology. The availability of a highly efficient, reliable, long-lived Ge/Ga generator system along with a well-established coordination chemistry based on bifunctional chelating agents have been the bases of this development in Ga radiopharmacy. Syntheses of Ga peptides were originally performed by manual or semiauto...

We present a conjecture, based on computational results, on the area minimizing way to enclose and separate two arbitrary volumes in the flat cubic three-torus T 3. For comparable small volumes, we prove that an area minimizing double bubble in T 3 is the standard double bubble from R 3 .