Cancer is the second leading cause of death globally and increasing every year, including in Indonesia. Promethium-149 (149Pm) one beta-emitting (Eβ-max 1.07 MeV T1/2 2.21 days) radiolanthanides that can be used for therapeutic application. Radioisotope 149Pm produced with high specific activity was suitable labeling biomolecule as a targeted radiopharmaceutical cancer therapy. Radiochemical se...

Methods of increasing the performance of radionuclide generators used in nuclear medicine radiotherapy and SPECT/PET imaging were developed and detailed for 99Mo/99mTc and 68Ge/68Ga radionuclide generators as the cases. Optimisation methods of the daughter nuclide build-up versus stand-by time and/or specific activity using mean progress functions were developed for increasing the performance o...

The performance of the Radionuclide Aerosol Sampler/Analyzer (RASA) under high-activity conditions has been evaluated to maintain and protect operations International Monitoring System (IMS) radionuclide stations. Station measurements following Fukushima Daichi accident 11 March 2011 have combined with laboratory understand how quality made using RASA High-Purity Germanium (HPGe) gamma-spectrom...

Background Radiotheragnostics makes use of the same molecular targeting vectors, labeled either with a diagnostic or therapeutic radionuclide, ideally of the same chemical element. The matched pair of scandium radionuclides, 44Sc and 47Sc, satisfies the desired physical aspects for PET imaging and radionuclide therapy, respectively. While the production and application of 44Sc was extensively s...

introduction: somatostatin receptors expressed on a wide range of human tumors, are potential targets for the peptide receptor radionuclide therapy (prrt). in this study, 177lu-[dota-dphe1, tyr3]octreotide (177lu-dotatoc) as an agent for prrt was prepared and its biodistribution was studied in rats. methods:the best condition for the preparation of the 177lu-dotatoc radiolabeled complex was det...

Presented here are recent experimental results on tests of a modified Cintichem process for producing Mo from low enriched uranium (LEU). Studies were focused in three areas: (1) testing the effects on Mo recovery and purity of dissolving LEU foil in nitric acid alone, rather than in the sulfuric/nitric acid mixture currently used, (2) measuring decontamination factors for radionuclide impuriti...

OBJECTIVES Recently, bone-avid radiopharmaceuticals have been shown to have potential benefits for the treatment of widespread bone metastases. Although (177)Lu-triethylene tetramine hexa methylene phosphonic acid (abbreviated as (177)Lu-TTHMP), as an agent for bone pain palliation, has been evaluated in previous studies, there are large discrepancies between the obtained results. In this study...

intoduction: therapeutic radiopharmaceuticals are radiolabeled molecules to deliver sufficient doses of ionizing radiation to specific disease sites such as bone metastases, brain and liver tumors and bone marrows malignancies including multiple myeloma. among some therapeutic radiopharmaceuticals, 166ho-1,4,7,10 -tetraazacyclo dodecane-1,4,7,10 tetraethylene phosphonic acid (166ho-dotmp) is us...

introduction: using labeled peptides enjoys high importance in nuclear medicine. somatostatin analogs labeled with different radionuclide are vastly investigated for diagnosis or treatment of somatostatin receptor positive tumors. labeling somatostatin analogs with 99mtc as alternative of 111in needs doing different quality control method for determination of labeling yield and complex stabilit...

Intoduction: Therapeutic radiopharmaceuticals are radiolabeled molecules to deliver sufficient doses of ionizing radiation to specific disease sites such as bone metastases, brain and liver tumors and bone marrows malignancies including multiple myeloma. Among some therapeutic radiopharmaceuticals, Ho-1,4,7,10 – tetraazacyclo dodecane–1,4,7,10 tetraethylene phosphonic acid (Ho-DOTMP) is used fo...