Tera Becquerel quantities of a number of radioisotopes such as 131I, 99Mo, 32P, 153Sm, 51Cr, 82Br, 203Hg, 140La, 46Sc, etc. are produced in various radiochemical forms and regularly supplied through Board of Radiation & Isotope Technology (BRIT) for applications in medicine, industry, biology, agriculture and research & development activities. These radioisotopes are produced by neutron activat...

Auger-electron-emitting radioisotopes provide a unique tool that enables the targeted irradiation of a small volume in their immediate vicinity. Over the last forty years, Auger emission has been established as a promising form of molecular radiotherapy, and it has recently made the transition from the laboratory to the clinic. In this paper we review the physical processes of Auger emission in...

The combination of the size-dependent properties of nanomaterials with radioisotopes is emerging as a novel tool for molecular imaging. There are numerous examples already showing how the controlled synthesis of nanoparticles and the incorporation of a radioisotope in the nanostructure offer new features beyond the simple addition of different components. Among the different nanomaterials, iron...

Whenever the body is irradiated, for diagnostic or therapeutic purposes, a considerable amount of bone and bone marrow is inevitably included in the field of the radiation beam. Furthermore, many of the radioisotopes used clinically become incorporated in bone, sometimes to a high degree. The physical consideration of this irradiation of bone is complex because (a) the increased radiation absor...

p53 inhibits division following cellular damage. Cultured cells were found to express p53 protein following pulse labelling with radioisotopes, even at low doses normally used for growth and metabolic labelling studies. Some stem cells are exquisitely sensitive to radiation and thus p53 may have evolved as a major regulator of stem cell function. Therefore any genetic damage may be able to indu...

Although more than 20 years have passed since radioisotopes were first used to study the deposition of aerosols in the respiratory tract of children,' such studies have only recently become relatively more common.2 The reason for this lies in the widespread concern regarding the use of radioisotopes for research purposes in childhood. Indeed, this concern is such that certain journals have reje...