Lung tumors are often associated with a poor prognosis although different schedules and treatment modalities have been extensively tested in the clinical practice. The complexity of this disease and the use of combined therapeutic approaches have been investigated and the use of high dose-rates is emerging as effective strategy. Technological improvements of clinical linear accelerators allow c...

We study the problem of finding an optimal radiotherapy treatment plan. A time-dependent Boltzmann particle transport model is used to model the interaction between radiative particles with tissue. This model allows for the modeling of inhomogeneities in the body and allows for anisotropic sources modeling distributed radiation—as in brachytherapy—and external beam sources—as in teletherapy. We...

Radiobiological researches with heavy ions have been started at ITEP in 2006 on unique heavy ion accelerating facility ITEP-TWAC. The main purpose of these researches is study of the biological efficiency of carbon ions for different types of biological objects, such as tumor and normal cells, in the framework of the development of heavy ion therapy for cancer treatment in Russia. Another possi...

The objective of microdosimetry was, and still is, to identify physical descriptions of the initial physical processes of ionising radiation interacting with biological matter which correlate with observed radiobiological effects with a view to improve the understanding of radiobiological mechanisms and effects. The introduction of therapy with particles starting with fast neutrons followed by ...

The space radiation environment imposes increased dangers of exposure to ionizing radiation, particularly during a solar particle event (SPE). These events consist primarily of low energy protons that produce a highly inhomogeneous dose distribution. Due to this inherent dose heterogeneity, experiments designed to investigate the radiobiological effects of SPE radiation present difficulties in ...

diation and radiobiological researches and radiation protection. The first two lines are included in the Topical Plan for Scientific Research of JINR and were concentrated on: • neutron spectrometry and radiometry, radiation monitoring; • investigation of radiation fields around thick targets; • physical support of radiobiological experiments; • shielding calculations and design; • investigatio...

Stochastic Modeling of the Cell Killing Effects of Low and High LET Radiation. (December 2004) Julien Partouche, Diplôme d’ingénieurs, Fondation EPF Chair of Advisory Committee: Dr. Dan Reece Theoretical modeling of biological response to radiation describes qualitatively and quantitatively the results of radiobiological effects at the molecular, chromosomal, and cellular level. The repair-misr...