The response of the brain to irradiation is complex, involving a multitude of stress inducible pathways that regulate neurotransmission within a dynamic microenvironment. While significant past work has detailed the consequences of CNS radiotherapy following relatively high doses (≥ 45 Gy), few studies have been conducted at much lower doses (≤ 2 Gy), where the response of the CNS (like many ot...

Background: ˝Radioadaptive Response˝ is well-documented phenomenon appeared in low dose ionizing radiation received in vitro and in vivo. Occupational exposure has always been a great concern for radiation workers therefore this study was performed to study radioadaptive response in terms of residual DNA double strand breaks as an endpoint in peripheral blood leukocytes of occupationally expose...

the adaptive response (ar) is a phenomenon by which cells exposure to sublethal doses of dna-damaging agents (non-mutagenic dose of chemical or radiation), known as conditioning treatment (ct), leads to increased resistance to a subsequent exposure to a higher dose of the same or other agents, known as challenge treatment (cr). the adaptive response (ar) induced by radiation in human lymphocyte...

Radioadaptive survival responses after relatively low doses of radiation were investigated in C57BL/6 mice. The 8-week-old mice received whole-body mid-lethal challenging irradiation (5.9 Gy) at various intervals after conditioning whole-body irradiation with 50-400 mGy. Thereafter, survival of the mice was observed for 30 days. The mice receiving 400 mGy at 6 h before the challenging dose had ...

In vivo neutron-induced radioadaptive response (RAR) was studied using zebrafish (Danio rerio) embryos. The Neutron exposure Accelerator System for Biological Effect Experiments (NASBEE) facility at the National Institute of Radiological Sciences (NIRS), Japan, was employed to provide 2-MeV neutrons. Neutron doses of 0.6, 1, 25, 50 and 100 mGy were chosen as priming doses. An X-ray dose of 2 Gy...

We found the alpha-particle priming dose which could effectively induce in vivo radioadaptive response in the embryos of the zebrafish, Danio rerio, to be 4.8e48 mGy, through the apoptotic signals scored in the embryos at 24 h post fertilization. Specially fabricated thin polyallyldiglycol carbonate (PADC) films were used as support substrates for the dechorionated embryos. During irradiation, ...