Aspartame (N-aspartyl-phenylalanine methyl ester), a widely used artificial sweetener, is hydrolyzed in the intestinal lumen to methanol and to its constituent amino .acids phenylalanine and aspartic acid. Ingestion of this sweetener causes a sharp increase in plasma phenylalanine I vels in normal persons. and in patients with phenylketonu ia.2The label on aspartame-containing products includes...

A new polyene pigment, melanocrocin, has been isolated either from fruit bodies or mycelial cultures of the subterranean fungus Melanogaster broomeianus. The structure of the pigment was determined by spectroscopic methods and chemical transformations. Melanocrocin is the N-acyl derivative of L-phenylalanine methyl ester with a polyolefinic carboxylic acid.

In this study, the antibacterial and cytotoxic activities of some amino acid methyl esters (L-methionine, L-phenylalanine, L-histidine, L-lysine, L-tryptophan, L-tyrosine) were investigated. The effect ester compounds on performance was determinated against Gram-negative Gram-positive bacteria. cell viability investigated cancerous non-cancerous lines using MTS assay. results showed substances ...

Pepsin reacts stoicheiometrically with the active-site-directed irreversible inhibitor N-diazoacetyl-l-phenylalanine methyl ester, with concomitant loss of all proteolytic and peptidolytic activity. The reagent esterifies a unique aspartic acid residue in pepsin, which is in the sequence:Ile-Val-Asp-Thr-Gly-Thr-Ser

We report here the single and combined antitumor activity on B16 melanoma in female C57BL/6 X DBA/2F1 mice bearing s.c. tumors of sodium ascorbate, carbidopa-levodopa methyl ester, and dietary phenylalanine and tyrosine deficiency. Groups of 15 mice were fed continuously one of three test diets both with and without sodium ascorbate (30 mg/ml) in the drinking water beginning 2 weeks before inoc...

We report here the single and combined antitumor activity on B16 melanoma in female C57BL/6 x DBA/2F! mice bearing s.c. tumors of sodium ascorbate, carbidopa-levodopa methyl ester, and dietary phenylalanine and tyrosine deficiency. Groups of 15 mice were fed continuously one of three test diets both with and without sodium ascorbate (30 mg/ml) in the drinking water beginning 2 weeks before inoc...

biofuels are the main substitute to fossil fuels. these fuels are less polluting in compari-son to fossil fuels and can be produced from agricultural material residues for use in die-sel engines. in this research work bioethanol was produced from potato waste. it was de-hydrated in a vapor phase using 3a zeolite and was used in combination with sunflower methyl ester oil and diesel fuel blendin...

In this issue of Microbial Cell, Koh and colleagues present data highlighting the utility of the lysosomotropic compound L-leucyl-L-leucyl methyl ester (LeuLeu-OMe) as an anti-Trypanosoma brucei agent, adding to the range of compounds that either directly target lysosomal enzymes or that can be used to subvert the function of the lysosome for parasite destruction.

A concise and stereoselective total synthesis of the clinically relevant tricyclic prostaglandin D2 metabolite (tricyclic-PGDM) methyl ester in racemic form was accomplished eight steps from a readily available known cyclopentene-diol derivative. The features nickel-catalyzed Ueno–Stork-type dicarbofunctionalization to generate two consecutive stereocenters, palladium-catalyzed carbonylative sp...