Transport infrastructure has represented one of the cornerstones of development and cohesion strategies in the European Union (EU) and elsewhere in the world. However, despite the considerable funds devoted to it, its impact remains controversial. This paper revisits the question of to what extent transport infrastructure endowment – proxied by regional motorways – has contributed to regional g...

A transportation network-multiregional CGE model is applied to estimate the network effects of a set of highway projects on the value-added by region and industrial sector for the construction and operation periods. Among nine highways in an east–west direction in Korea, the East–West 9 highway increases the GDP by 0.300% over the 30-period time horizon with 0.016% of the GDP as the network eff...

Colicin E3 is a cytotoxic ribonuclease that specifically cleaves 16S rRNA at the ribosomal A-site to abolish protein synthesis in sensitive Escherichia coli cells. We have performed extensive mutagenesis of the 96-residue colicin E3 cytotoxic domain (E3 rRNase), assayed mutant colicins for in vivo cytotoxicity, and tested the corresponding E3 rRNase domains for their ability to inactivate ribos...

Different hypotheses of carcinogenesis have been proposed based on local genetic factors and physiologic mechanisms. It is assumed that changes in the metric invariants a biologic system (BS) determine general mechanisms cancer development. Numerous pieces data demonstrate existence three invariant feedback patterns BS: negative (NFB), positive (PFB) reciprocal links (RL). These base represent ...

Introduction: Seasonal variation of benign paroxysmal positional vertigo (BPPV) presentation has been reported, with higher rates in months associated times lower serum vitamin D levels. The purpose this study was to examine the association between timing hip fracture patients BPPV. Methods: A retrospective review (2013 2019) adult performed at a tertiary care academic center identify due groun...

To date, systematic evaluations of regeneration policies and programs for industrial sites are scarce. This is particularly the case for evaluations that aim to examine whether policy objectives are actually achieved and to what extent this was due to the implementation of that policy or program. Regeneration policies and programs for these sites usually involve public provision of infrastructu...

In order to elucidate the molecular mechanism of the catalytic reaction and enzyme conformation, we substituted 53 conserved residues identified by aligning 92 p-hydroxybenzoate hydroxylase sequences and 19 non-conserved residues selected from crystallographic studies of Pseudomonas fluorescens NBRC14160 p-hydroxybenzoate hydroxylase with 19 other naturally occurring amino acids, yielding a dat...

MicroRNAs (miRNAs) are a recently discovered set of regulatory genes that constitute up to an estimated 1% of the total number of genes in animal genomes, including Caenorhabditis elegans, Drosophila, mouse, and humans [Lagos-Quintana, M., Rauhut, R., Lendeckel, W. & Tuschl, T. (2001) Science 294, 853-858; Lai, E. C., Tomancak, P., Williams, R. W. & Rubin, G.M. (2003) Genome Biol. 4, R42; Lau, ...

We consider price and service-quality setting in oligopolistic markets for congestible services, applied to the case of private roads. Previous studies show that parallel competitors set a volume/capacity ratio (and thereby a travel time or service quality) that is socially optimal if they take the actions of the others as given. We find that this result does not hold when capacity and toll set...

The acuABC genes of Bacillus subtilis comprise a putative posttranslational modification system. The AcuA protein is a member of the Gcn5-related N-acetyltransferase (GNAT) superfamily, the AcuC protein is a class I histone deacetylase, and the role of the AcuB protein is not known. AcuA controls the activity of acetyl coenzyme A synthetase (AcsA; EC 6.2.1.1) in this bacterium by acetylating re...