Glycine is taken up twice as rapidly by neurons R3-R14 as by other identified neurons in the Aplysia parietovisceral ganglion. Earlier studies had shown that R3R14 have much higher glycine concentrations than other Aplysia neurons. Most of the glycine taken up by R3-R14 was biochemically untransformed for at least 1 h following its uptake. Glycine is actively transported into R3-R14 and other A...

Some approaches to the synthesis of tetracycline are described. Tetracycline [(I), R' = Me, R2 = R3 = H] is a member of the important group of tetracycline antibiotics. Other members of this group of medicinal importance are aureomycin [(I). R' = Me, R2 = H, R3 = Cl], terramycin [(I), R' = Me, R2 = OH, R3 = H] and 6-demethyltetracycline [(I)], R1 = R2 = R3 = H]. All these compounds represent ch...

Recently, we described the receptor for hyaluronic acid-mediated motility (RHAMM) as a leukemia-associated antigen and characterized the RHAMM-derived peptide R3 (pos. 165-173: ILSLELMKL) as a CD8+ T cell epitope. Directing CD8+ T lymphocytes specifically to R3 might help to shape the graft-versus-leukemia effect observed after allogeneic stem cell transplantation (allo-SCT). To detect the pote...

The major obstacle to developing siRNA delivery is their extracellular and intracellular barriers. Herein, a humanized anti-EGFR monoclonal antibody h-R3 was developed to modify the self-assembled binary complexes (dendriplexes) of PAMAM and siRNA via electrostatic interactions, and two common ligands HSA and EGF were used as a control. Compared to dendriplexes, h-R3/EGF/HSA-dendriplexes showed...

The conormal Lagrangian LK of a knotK in R3 is the submanifold of the cotangent bundle T ∗R3 consisting of covectors along K that annihilate tangent vectors to K. By intersecting with the unit cotangent bundle S∗R3, one obtains the unit conormal ΛK , and the Legendrian contact homology of ΛK is a knot invariant of K, known as knot contact homology. We define a version of string topology for str...

Within the developing vertebrate head, the migration of neural tube-derived neural crest cells (NCCs) through the cranial mesenchyme is patterned into three streams, with mesenchyme adjacent to rhombomeres (r)3 and r5 maintained NCC-free. The receptor tyrosine kinase erbB4 is expressed within r3 and r5 and is required to maintain the r3-adjacent NCC-free zone in mouse embryos. In this study, we...

Epidermis cell differentiation in Arabidopsis thaliana is a model system for understanding the developmental end state of plant cells. Two types of MYB transcription factors, R2R3-MYB and R3-MYB, are involved in cell fate determination. To examine the molecular basis of this process, we analyzed the functional relationship of the R2R3-type MYB gene WEREWOLF (WER) and the R3-type MYB gene CAPRIC...

TRAIL-R3, a new member of the TRAIL receptor family, has been cloned and characterized. TRAIL-R3 encodes a 299 amino acid protein with 58 and 54% overall identity to TRAIL-R1 and -R2, respectively. Transient expression and quantitative binding studies show TRAIL-R3 to be a plasma membrane-bound protein capable of high affinity interaction with the TRAIL ligand. The TRAIL-R3 gene maps to human c...

We show that a suitable weak solution to the incompressible Navier–Stokes equations on R3×(?1,1) is regular R3×(?1,0] if ?3u belongs M2p/(2p?3),?((?1,0);Lp(R3)) for any ?>1 and p?(3/2,?), which logarithmic-type variation of Morrey space in time. For each this is, up logarithm, critical with respect scaling equations, contains all spaces Lq((?1,0);Lp(R3)) are subcritical, 2/q+3/p<2.

Within the developing vertebrate head, neural crest cells (NCCs) migrate from the dorsal surface of the hindbrain into the mesenchyme adjacent to rhombomeres (r)1 plus r2, r4 and r6 in three segregated streams. NCCs do not enter the intervening mesenchyme adjacent to r3 or r5, suggesting that these regions contain a NCC-repulsive activity. We have used surgical manipulations in the chick to dem...