BACKGROUND Although gelatin-resorcinol-formaldehyde (GRF) glue is used for surgical repair of acute type A aortic dissections, late complications possibly ascribed to toxic effects of GRF glue have been reported. We analyzed the benefits and risks of using GRF glue. PATIENTS AND METHODS Between January 1990 and August 2003, 269 consecutive patients underwent emergency operations for acute typ...

Growth-regulating factor (GRF) genes play a regulatory role for plant growth and development. The recently available cucumber, melon and watermelon genomes provide an opportunity to conduct a comprehensive overview of the GRF gene family. In the present study, identification and analysis of the GRF gene family was conducted using bioinformatics methods. Totally, 24 potential GRF genes were iden...

Human growth hormone releasing hormone (GRF 1-44 or GRF 1-29) was administered to lambs at two different physiological stages (suckling: 5-6 week-old and weaned: 14-15 week-old) when growth hormone (GH) secretory patterns were different: suckling lambs exhibited flat basal GH profiles (5-10 ng/ml) while the weaned lambs had frequent spontaneous episodes of GH release (15-65 ng/ml). The iv injec...

Three-dimensional ground reaction forces (3D-GRF) are essential for functional evaluation for rehabilitation. A platform path is required to obtain the 3D-GRF. The main shortcoming of these platform paths is that during double stance phases of gait, both feet can be placed on the same force platform causing the need for decomposing the 3D-GRF under each foot. Despite the high number of studies ...

Quantitative structure activity relationship (QSAR) studies of twenty four 5-cyano, N1, 6disubstituted, 2-thiouracil derivatives were performed for their central nervous system (CNS) depressant (locomotor) activity using VlifeMDS3.5 software. Partial least square (PLS) linear regression analysis coupled with stepwise variable selection method was applied to derive QSAR models which were further...

The precise control of gene regulation, and hence, correct spatiotemporal tissue patterning, is crucial for plant development. Plant microRNAs can constrain the expression of their target genes at posttranscriptional levels. Recently, microRNA396 (miR396) has been characterized to regulate leaf development by mediating cleavage of its GROWTH-REGULATING FACTOR (GRF) targets. miR396 is also prefe...

Using an explant culture system, we have demonstrated that human somatotropes respond to growth hormone releasing factor (GRF) and somatostatin (SRIF) from as early as 9.5 weeks of fetal age. Responsiveness to GRF increases significantly as a function of age up to midgestation while SRIF inhibition of basal growth hormone (GH) release does not change. SRIF has little effect on GRF-stimulated GH...

GH-releasing factor (GRF) is the hypothalamic peptide that stimulates both synthesis and secretion of GH. The GRF signal is transduced to somatotroph cells through pituitary GRF receptors and generates episodic bursts of GH secretion into the bloodstream. Secretion of GH is highly sexually dimorphic, particularly in the rat [1]. In female rats, GH surges are of lower amplitude and occur more ir...

The gait cycle prediction model is critical for controlling assistive rehabilitation equipment like orthosis. human has recently used statistical models, but the dynamic properties of physiology limit current approach. Current models need detailed kinematic and kinetic data body as input parameters, measuring them requires special instruments, making difficult to use in real-world applications....

Despite extensive research on running mechanics, there is still a knowledge gap with respect to the degree of relationship between mediolateral ground reaction forces (ML-GRF) and foot pronation. Our goal was to investigate whether differences exist in ML-GRF among runners that exhibit different degrees of pronation. Seventeen male and 13 female recreational runners ran with and without shoes w...