several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-fu related toxicity. the aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-fu in rabbits, mice and dogs. it was further aimed to determine its route related toxicity in rabbits.    plasma concentration of both 5-fu and its metabolite 5-f...

introduction: natural biomaterials and growth factors are key factors in tissue engineering. the objective of the present study was to evaluate transforming growth factor beta 1 (tgf-β1) and curcumin on proliferation and differentiation of nasal-derived chondrocyte seeded on the fibrin glue scaffold. methods: chondrocytes were isolated from nasal samples. nasal-derived chondrocytes were seeded ...

the complexation reactions between mg2+, ca2+, sr2+ and ba2+ metal cations with 15-crown-5 (15c5) were studied in acetonitrile (an)-methanol (meoh) binary mixtures at different temperatures using conductometric method. 15c54 forms 1:1 complexes with mg2+, ca2+ and sr2+ cations in solutions. the ma2+ cation forms a 2:1 complex (ratio of lighand to cation) in solutions. a linear relation was obse...

background: there are many studies to investigate the effects of each interacting component of tumor-immune system interactions. in all these studies, the distinct effect of each component was investigated. as the interaction of tumor-immune system has feedback and is complex, the alternation of each component may affect other components indirectly. objective: because of the complexities of tum...

introduction: for thousands of years, plants have been used as the main source of drug worldwide. recently, it has been found out that the plant artemisia annua and especially its derivatives such as artemether have anticancer properties. methods: in this study, the anticancer effect of artemether on mcf-7 breast cancer cell line was examined. mtt assay was used to assess the viability of cance...

in this study, aluminosilicate mcm-41 has been found to be an efficient catalyst for reaction betweendifferent benzaldehyde derivatives and 5,5-dimethyl-1,3-cyclohexanedione to give open chain analogue of1,8-dioxo-octahydroxanthene in excellent yields. no evidence for the formation of cyclization products wasobserved. the catalyst can be used several times after recovery.

background: colorectal cancer is one of the most important causes of morbidity and mortality in the world. it has been suggested that tissue inhibitor of metalloproteinase-1 (timp-1) plays a particular role in cancer promotion. the objective of the present study was to compare the effect of repeated measurement of carcinoembryonic antigen (cea) and timp-1 plasma levels in a follow-up response t...