OBJECTIVES Oral quinine is used for the treatment of uncomplicated malaria during pregnancy, but few pharmacokinetic data are available for this population. Previous studies have reported a substantial effect of malaria on the pharmacokinetics of quinine resulting from increased α-1-acid glycoprotein levels and decreased cytochrome P450 3A4 activity. The aim of this study was to investigate the...

The chincona alkaloid quinine is known to be a bitter tasting substance for various vertebrates. We examined the effects of quinine on isolated taste receptor cells from the bullfrog (Rana catesbeiana). Membrane currents were recorded by whole-cell recording, while quinine hydrochloride was applied extracellularly from a puffer pipette. At the resting potential (-77 +/- 9 mV, mean +/- SD, n = 4...

Tripodal pyrrole imine and amide ligands provide platforms for combined primary and secondary coordination sphere interactions in square planar Pd and Cu, and octahedral Ti complexes.

A non-aqueous capillary electrophoretic method developed with quinine and tert.-butyl carbamoylated quinine as chiral selectors for the enantioseparation of N-protected amino acids was applied to the investigation of other quinine derivatives as chiral additives. The optimum composition of the background electrolyte was found to be 12.5 mM ammonia, 100 mM octanoic acid and 10 mM chiral selector...

Practice Pointers Muscle cramps affect between 50% and 60% of adults.1 Little is known about their pathophysiology, so many remedies are used empirically. A crystalline alkaloid powder extracted from the bark of the South American cinchona tree, quinine is well known for its use in treating malaria and providing the bitter flavor for tonic water. Quinine has been used by the Quechua of South Am...

Quinine is widely used for the common symptom of leg cramps. Quinine tablets require a prescription, but quinine and the product from which it is derived, cinchona, are also available without prescription. They are components of over-the-counter remedies for many common symptoms, of nutrition products, and of beverages such as tonic water and bitter lemon. Although quinine has been used for cen...

Quinine is a bitter tasting compound that is involved in the regulation of body weight as demonstrated in in vivo animal models and in vitro models of the adipogenic system. Arguments exist over the positive or negative roles of quinine in both in vivo animal models and in vitro cell models, which motivates us to further investigate the functions of quinine in the in vitro adipogenic system. To...

6th June, 1925.?No response to quinine (grs. 5 t.d.s.) given from 2nd June, 1925, 9-30 p.m. Temperature 106?F. Intravenous injection of quinine bihydrochloride (grs. 3). 7th June, 1925.?8 a.;m. Temperature 98.6?F. Intravenous injection of quinine bihydrochloride (grs. 2i). Urine now distinctly "milky," showed marked chyluria and the microscope revealed a large number of microfilariae. The quini...

A novel platinum-mediated process involving intermolecular activation of a C(aryl)-H bond of toluene, intramolecular activation of an imine C(aryl)-Cl bond and formation of a C-C bond is reported.