نتایج جستجو برای: quic root
تعداد نتایج: 139075 فیلتر نتایج به سال:
*Correspondence to: Ryuichiro Atarashi; Email: [email protected] We recently developed a new in vitro amplification technology, designated “real-time quaking-induced conversion (RT-QUIC),” for detection of the abnormal form of prion protein (PrP) in easily accessible specimens such as cerebrospinal fluid (CSF). After assessment of more than 200 CSF specimens from Japanese and Australian...
This paper presents the performance evaluation of Quick UDP Internet Connections (QUIC), SCTP, TCP and TCP-Reno within Cloud and Cloudlet services. We first present the transport protocols and a comparison between Cloud and Cloudlet. Secondly, we assess the performance of QUIC compared to SPDY and TCP in terms of transport time decrease. Then, we present a simulation setting for energy aware us...
Approximation of matrices using the Singular Value Decomposition (SVD) plays a central role in many science and engineering applications. However, the computation cost of an exact SVD is prohibitively high for very large matrices. In this paper, we describe a GPU-based approximate SVD algorithm for large matrices. Our method is based on the QUIC-SVD introduced by [6], which exploits a tree-base...
Chronic wasting disease (CWD) is an efficiently transmitted prion disease of cervids, now identified in 22 United States, 2 Canadian provinces and Korea. One hallmark of CWD is the shedding of infectious prions in saliva, as demonstrated by bioassay in deer. It is also clear that the concentration of prions in saliva, blood, urine and feces is much lower than in the nervous system or lymphoid t...
Prions composed of pathogenic scrapie prion protein (PrPSc) are infectious pathogens that cause progressive neurological conditions known as prion diseases or transmissible spongiform encephalopathies. Although these diseases pose considerable risk to public health, procedures for early diagnosis have not been established. One of the most recent attempts at sensitive and specific detection of p...
Real-Time Quaking-Induced Conversion (RT-QuIC) testing of human cerebrospinal fluid (CSF) is highly sensitive and specific in discriminating sporadic CJD patients from those without prion disease. Here, using CSF samples from 113 CJD and 64 non-prion disease patients, we provide the first direct and concurrent comparison of our improved RT-QuIC assay to our previous assay, which is similar to t...
The widespread deployment of end-to-end encryption protocols such as HTTPS and QUIC has reduced the visibility for operators into traffic on their networks. Network operators need the visibility to monitor and mitigate Quality of Experience (QoE) impairments in popular applications such as video streaming. To address this problem, we propose a machine learning based approach to monitor QoE metr...
The ability of PrP to convert PrP into protease-resistance isoforms has been exploited using a variety of techniques such as protein misfolding cyclic amplification (PMCA), quaking induced conversion (QuIC) and most recently, real-time quaking induced conversion (RT-QuIC). These cell-free assays have enabled a better understanding of prion diseases and have facilitated the development of potent...
Different transmissible spongiform encephalopathy (TSE)-associated forms of prion protein (e.g. PrP(Sc)) can vary markedly in ultrastructure and biochemical characteristics, but each is propagated in the host. PrP(Sc) propagation involves conversion from its normal isoform, PrP(C), by a seeded or templated polymerization mechanism. Such a mechanism is also the basis of the RT-QuIC and eQuIC pri...
The Singular Value Decomposition is a key operation in many machine learning methods. Its computational cost, however, makes it unscalable and impractical for applications involving large datasets or real-time responsiveness, which are becoming increasingly common. We present a new method, QUIC-SVD, for fast approximation of the whole-matrix SVD based on a new sampling mechanism called the cosi...
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