Background: Acute myeloid leukemia (AML) is one of myeloid malignancies which the risk increases with age increment. It is categorized based on genetic aberrations. Some of these genetic disorders can determine minimal residual diseases (MRD) and prognosis of AML patients. Wilms tumor (WT1) over expression is found in AML patients. The aim of this study was to determine the frequency of WT1 ove...

In 183 male progeny derived from a backcross between the FGS/Kist strain, a new mouse model for focal glomerulosclerosis (FGS) in humans, and the standard normal strain, C57BL/6J, we performed a genome-wide scan for quantitative trait loci (QTLs) affecting the glomerulosclerosis index (GSI) based on histological observation as well as kidney and body weights. Two QTLs for GSI (Gsi1-2) located o...

Treating mRNA transcript abundances as quantitative traits and mapping gene expression quantitative trait loci for these traits has been studied in many species from yeast to humans. There has been significant success in finding associations between gene expression and genetic markers. These eQTL studies have been used to identify candidate causal regulators, to construct gene regulation networ...

Most frequently applied ultrasonic inspection techniques measure the reflectivity of geometric scatterers that are caused by impurities, flaws and defects in the material. Based on the echo sounder principles, the reflector has to be insonified by directed sound pulses. This requires a large number of transducers with different incident angles and sound field patterns, which are more and more r...

The sensitivity of analysis achievable with PCR has led to the technology being adopted across a range of sectors. For many applications a quantitative result is required, which has driven the development of a range of strategies to determine the amount of starting material in a sample. Approaches such as competitive PCR and limiting dilution analysis have been used as routes to quantification,...