OBJECTIVE To assess the comparative effectiveness and cost-effectiveness (cost-utility) of a 0.05% emulsion of topical cyclosporine (Restasis; Allergan Inc, Irvine, California) for the treatment of moderate to severe dry eye syndrome that is unresponsive to conventional therapy. METHODS Data from 2 multicenter, randomized, clinical trials and Food and Drug Administration files for topical cyc...

PURPOSE To compute cost-effectiveness/cost-utility (CE/CU) ratios, from the treatment clinic and societal perspectives, for high-dose palliative radiotherapy treatment (RT) for advanced non-small-cell lung cancer (NSCLC) against best supportive care (BSC) as comparator, and thereby demonstrate a method for computing CE/CU ratios when randomized clinical trial (RCT) data cannot be generated. M...

BACKGROUND Practice guidelines recommending Mycobacterium avium complex (MAC) prophylaxis for patients with HIV disease were based on clinical trials in which individuals did not receive protease inhibitors. OBJECTIVE To estimate the cost-effectiveness of strategies for MAC prophylaxis in patients whose treatment regimen includes protease inhibitors. DESIGN Decision analysis with Markov mod...

BACKGROUND Techniques to preserve the sub-valvular apparatus in order to reduce morbidity and mortality following mitral valve replacement have been frequently reported. However, it is uncertain what impact sub-valvular apparatus preservation techniques have on long-term outcomes following mitral valve replacement. This study investigated the effect of sub-valvular apparatus preservation on lon...

M for evaluating health quality are central to medical decision analyses. The most important such method is the quality-adjusted life year (QALY), in which a patient’s length of life is given weight proportional to his/her quality of health. QALYs have become ubiquitous in medical cost-effectiveness as a measure of preference for health outcomes. However, numerous studies have demonstrated that...

Methods for evaluating health quality are central to medical decision analyses. The most important such method is the quality-adjusted life year (or QALY), in which a patient's length of life is given weight proportional to quality of health. QALYs have become ubiquitous in medical cost-effectiveness as a measure of preference for health outcomes. However, numerous studies have demonstrated tha...

BACKGROUND AND PURPOSE To evaluate the influence of rhegmatogenous retinal detachment (RRD) surgery on elderly patients in terms of visual acuity, vision-related quality of life and its cost-effectiveness. METHODS Elderly patients over 70 years old, who were diagnosed and underwent RRD surgery at Shanghai First People's Hospital, Shanghai Jiao Tong University, China, from January 1, 2009, thr...

Background The use of quality-adjusted life years (QALY) as an outcome measure of economic evaluations is well-established in the literature. A measure of dental utility analogous to QALY, the quality-adjusted tooth years (QATY), had been initiated but only met with limited success, partly because of its inability to compare across a variety of dental interventions. This study aimed to develop ...

OBJECTIVE To estimate the willingness to pay (WTP) per quality-adjusted life year (QALY) value for life-saving treatments and to determine factors affecting the WTP per QALY value. DESIGN A cross-sectional survey with multistage sampling and face-to-face interviews. SETTING General population in the southern part of Thailand. PARTICIPANTS A total of 600 individuals were included in the st...

Abstract Background The best HbA1c test interval strategy for detecting new type 2 diabetes mellitus (T2DM) cases in healthy individuals should be determined with consideration of characteristics, risk stratification towards T2DM and cost effectiveness. Methods State transition models were constructed to investigate the optimal screening among each age- BMI-stratified health individuals. Age wa...