A case of primary myelofibrosis was identified with a previously unreported complex karyotype with two abnormal clones in addition to a proportion of normal cells: 46,XY, 2, 1 1, + der(2)t(2; 1) (q24/31;q13), + mar and 45,XY, 2, 1 1, + der(2)t(2;1 1)(q24/31;q13), + mar, 17,del(7q). Study of circulating committed progenitors from this patient consistently showed (1) an absence of erythroid proge...

t(11;22)(q24;q12) FLI1-EWSR1 85 ETS t(21;22)(q22;q12) ERG-EWSR1 5–15 t(7;22)(p22;q12) ETV1-EWSR1 <1 t(17;22)(q12;q12) E1AF-EWSR1 <1 t(2;22)(q33;q12) FEV-EWSR1 <1 patients and characterized by adverse outcome. Recently our understanding of molecular pathogenesis of Ewing sarcoma has greatly progressed, and there have been some promising therapeutic advances. The cytogenetic hallmark of Ewing sar...

Variant Burkitt-type translocation, t(8;22)(q24;q11), is very rare in plasma cell myeloma. We report a 51-year-old male patient with plasma cell myeloma, who showed t(8;22) (q24;q11). He suffered from pelvic pain for two months, and showed IgG, lambda type of monoclonal gammopathy (5.14 g/dL; 49.9% of protein). His bone marrow examination showed increased plasma cells (66.9% of all nucleated ce...

From its inception palliative care has been understood as addressing four dimensions: physical, social, emotional/psychological, and spiritual/religious. However, the spiritual and/or religious element is poorly under-researched, little known about professionals’ understandings of care, or how they seek to implement in practice. Members European Association Palliative Care (EAPC) Spiritual Task...